The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split‐face pilot study

Background Enoxolone, derived from licorice, possesses potent anti‐inflammatory, and antioxidant properties. However, its effectiveness in alleviating post‐laser reactions has not been extensively studied. Aims This randomized split‐face pilot study aimed to evaluate the effects of enoxolone on skin following laser treatment. Patients/Methods Ten healthy subjects underwent non‐ablative 1550 nm Er:Glass fractional laser treatment and then randomly applied a moisturizer without enoxolone on one side of the face and a dermo‐cosmetic formular containing 2% enoxolone mixed with the same moisturizer on the other side. The erythema index (EI), clinician's erythema assessment (CEA), and pain scores were recorded at 30 min, 60 min, and 24 h posttreatment. Results The group treated with enoxolone showed significantly lower EI and CEA compared to the control group at 24 h posttreatment. Additionally, pain scores were notably reduced in the enoxolone‐treated group 30 min after treatment. Conclusions This study suggests that dermo‐cosmetic formular containing 2% enoxolone is effective in reducing erythema and pain following laser treatment.