Natural product-inspired molecules for covalent inhibition of SHP2 tyrosine phosphatase

Natural products have been playing indispensable roles in the development of lifesaving drug molecules. They are also valuable sources for covalent protein modifiers. However, they often are scarce in nature and have complex chemical structures, which are limiting their further biomedical developmen...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Tetrahedron 2024-04, Vol.156, p.133918, Article 133918
Hauptverfasser:	Liang, Weida, Krabill, Aaron D., Gallagher, Katelyn S., Muli, Christine, Qu, Zihan, Trader, Darci, Zhang, Zhong-Yin, Dai, Mingji
Format:	Artikel
Sprache:	eng
Schlagworte:	Covalent library Ent-kaurene diterpenoid Natural product Phosphatase SHP2
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!