Evaluation of Age and Gender-Related Patterns in Clinical Features and Hematological Findings Among Hypothyroidism Patients in the Al-Jouf Region of Saudi Arabia: A Hospital-Based Study
The prevalence of hypothyroidism is high in Saudi Arabia and the contributing factors are iodine deficiency and lack of balanced nutrition. This study aims to correlate the gender, age, and presence of co-morbidities with the laboratory findings and clinical presentation. A cross-sectional study was...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2024-03, Vol.16 (3), p.e56161-e56161 |
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| description | The prevalence of hypothyroidism is high in Saudi Arabia and the contributing factors are iodine deficiency and lack of balanced nutrition. This study aims to correlate the gender, age, and presence of co-morbidities with the laboratory findings and clinical presentation.
A cross-sectional study was done in the hospitals of the Al-Jouf region. The files of the patients diagnosed with hypothyroidism from the last two years were retrieved by non-probability consecutive sampling technique. IBM SPSS Statistics for Windows, Version 23, (Released 2015; IBM Corp., Armonk, New York, United States) was used for data entry and analysis. Descriptive statistics were presented as frequencies and proportions (for qualitative variables) and mean and standard deviation (SD) (for continuous data). Associated factors were identified through a chi-square test. A p-value less than 0.05 was considered statistically significant.
Most of the patients were females within the age group of 36 to 50 years. Significant differences were observed between male and female patients with respect to the FT4 levels, hemoglobin (Hb) levels, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) values, and RBC counts (p-values of |
| doi_str_mv | 10.7759/cureus.56161 |
| format | Article |
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A cross-sectional study was done in the hospitals of the Al-Jouf region. The files of the patients diagnosed with hypothyroidism from the last two years were retrieved by non-probability consecutive sampling technique. IBM SPSS Statistics for Windows, Version 23, (Released 2015; IBM Corp., Armonk, New York, United States) was used for data entry and analysis. Descriptive statistics were presented as frequencies and proportions (for qualitative variables) and mean and standard deviation (SD) (for continuous data). Associated factors were identified through a chi-square test. A p-value less than 0.05 was considered statistically significant.
Most of the patients were females within the age group of 36 to 50 years. Significant differences were observed between male and female patients with respect to the FT4 levels, hemoglobin (Hb) levels, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) values, and RBC counts (p-values of <0.001, <0.001, <0.001, <0.001, <0.001 and <0.001, respectively). However, no significant differences were observed between male and female patients in the TSH levels and hematocrit values. Most of the patients were euthyroid (77.24%). The pattern of thyroid function status did not show significant differences with respect to the gender of participants and the different age groups (p-values of 0.447 and 0.775, respectively). The most common co-morbidities observed were diabetes and hypertension. No significant association between the co-morbidities and the pattern of thyroid function status was observed. The most common symptoms were epigastric pain, fatigue, constipation, drowsiness, altered bowel habits, and weight gain.
This hospital-based study provides valuable insights into some epidemiological characteristics, clinical features, and hematological findings in hypothyroidism patients of the Al-Jouf region. Significant differences were observed between male and female patients with respect to the FT4 levels, Hb levels, MCV, MCH, MCHC values, and RBC counts. The findings strengthen the existing knowledge base and emphasize the importance of timely detection and management of hypothyroidism in this population. Implementation of salt iodination programs and a timely evaluation of the hematological parameters is recommended. Further research is warranted to delve into the hidden mechanisms and long-term ramifications of hematological changes associated with hypothyroidism.]]></description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.56161</identifier><identifier>PMID: 38618448</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Age groups ; Blood ; Chronic illnesses ; Diabetes ; Family medical history ; Females ; Gender ; Hematology ; Hemoglobin ; Hormones ; Hypertension ; Hypothyroidism ; Iodine ; Kidney diseases ; Metabolism ; Morbidity ; Patients ; Thyroid diseases</subject><ispartof>Curēus (Palo Alto, CA), 2024-03, Vol.16 (3), p.e56161-e56161</ispartof><rights>Copyright © 2024, Wani et al.</rights><rights>Copyright © 2024, Wani et al. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c244t-7412dba5566d34c8f2904f4993ff9efa46b8512f424ab3013508c62385e3ccf73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38618448$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wani, Farooq A</creatorcontrib><creatorcontrib>Thirunavukkarasu, Ashokkumar</creatorcontrib><creatorcontrib>Alrashed, Hatim</creatorcontrib><creatorcontrib>Alblwan, Abdalrhman S</creatorcontrib><creatorcontrib>Alfuhigi, Yazeed M</creatorcontrib><creatorcontrib>Dilli, Mohammed</creatorcontrib><creatorcontrib>Alruwaili, Layth</creatorcontrib><title>Evaluation of Age and Gender-Related Patterns in Clinical Features and Hematological Findings Among Hypothyroidism Patients in the Al-Jouf Region of Saudi Arabia: A Hospital-Based Study</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description><![CDATA[The prevalence of hypothyroidism is high in Saudi Arabia and the contributing factors are iodine deficiency and lack of balanced nutrition. This study aims to correlate the gender, age, and presence of co-morbidities with the laboratory findings and clinical presentation.
A cross-sectional study was done in the hospitals of the Al-Jouf region. The files of the patients diagnosed with hypothyroidism from the last two years were retrieved by non-probability consecutive sampling technique. IBM SPSS Statistics for Windows, Version 23, (Released 2015; IBM Corp., Armonk, New York, United States) was used for data entry and analysis. Descriptive statistics were presented as frequencies and proportions (for qualitative variables) and mean and standard deviation (SD) (for continuous data). Associated factors were identified through a chi-square test. A p-value less than 0.05 was considered statistically significant.
Most of the patients were females within the age group of 36 to 50 years. Significant differences were observed between male and female patients with respect to the FT4 levels, hemoglobin (Hb) levels, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) values, and RBC counts (p-values of <0.001, <0.001, <0.001, <0.001, <0.001 and <0.001, respectively). However, no significant differences were observed between male and female patients in the TSH levels and hematocrit values. Most of the patients were euthyroid (77.24%). The pattern of thyroid function status did not show significant differences with respect to the gender of participants and the different age groups (p-values of 0.447 and 0.775, respectively). The most common co-morbidities observed were diabetes and hypertension. No significant association between the co-morbidities and the pattern of thyroid function status was observed. The most common symptoms were epigastric pain, fatigue, constipation, drowsiness, altered bowel habits, and weight gain.
This hospital-based study provides valuable insights into some epidemiological characteristics, clinical features, and hematological findings in hypothyroidism patients of the Al-Jouf region. Significant differences were observed between male and female patients with respect to the FT4 levels, Hb levels, MCV, MCH, MCHC values, and RBC counts. The findings strengthen the existing knowledge base and emphasize the importance of timely detection and management of hypothyroidism in this population. Implementation of salt iodination programs and a timely evaluation of the hematological parameters is recommended. Further research is warranted to delve into the hidden mechanisms and long-term ramifications of hematological changes associated with hypothyroidism.]]></description><subject>Age groups</subject><subject>Blood</subject><subject>Chronic illnesses</subject><subject>Diabetes</subject><subject>Family medical history</subject><subject>Females</subject><subject>Gender</subject><subject>Hematology</subject><subject>Hemoglobin</subject><subject>Hormones</subject><subject>Hypertension</subject><subject>Hypothyroidism</subject><subject>Iodine</subject><subject>Kidney diseases</subject><subject>Metabolism</subject><subject>Morbidity</subject><subject>Patients</subject><subject>Thyroid diseases</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkU9v1DAQxSMEolXpjTOyxIUDKXbsJA63dNV2QZVALZyjSTzeunLsxX-Q9qPx7Uh3F4Q4zUjvN2-e9IriNaMXbVt3H6YcMMeLumENe1acVqyRpWRSPP9nPynOY3yklDLaVrSlL4sTLptFEPK0-HX1E2yGZLwjXpN-gwScIjfoFIbyDi0kVOQrpITBRWIcWVnjzASWXCOk5X3cH6xxhuSt3xwk45Rxm0j62bsNWe-2Pj3sgjfKxPnJzaBLe7f0gKS35WefNbnDzTHGPWRlSB9gNPCR9GTt49YksOUlxCXOfcpq96p4ocFGPD_Os-L79dW31bq8_XLzadXfllMlRCpbwSo1Ql03jeJikrrqqNCi67jWHWoQzShrVmlRCRg5ZbymcmoqLmvk06Rbfla8O_hug_-RMaZhNnFCa8Ghz3HglHcVb6kQC_r2P_TR5-CWdAslulbyTrCFen-gpuBjDKiHbTAzhN3A6PDU6nBoddi3uuBvjqZ5nFH9hf90yH8DqdmfJw</recordid><startdate>20240314</startdate><enddate>20240314</enddate><creator>Wani, Farooq A</creator><creator>Thirunavukkarasu, Ashokkumar</creator><creator>Alrashed, Hatim</creator><creator>Alblwan, Abdalrhman S</creator><creator>Alfuhigi, Yazeed M</creator><creator>Dilli, Mohammed</creator><creator>Alruwaili, Layth</creator><general>Cureus Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PKEHL</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20240314</creationdate><title>Evaluation of Age and Gender-Related Patterns in Clinical Features and Hematological Findings Among Hypothyroidism Patients in the Al-Jouf Region of Saudi Arabia: A Hospital-Based Study</title><author>Wani, Farooq A ; Thirunavukkarasu, Ashokkumar ; Alrashed, Hatim ; Alblwan, Abdalrhman S ; Alfuhigi, Yazeed M ; Dilli, Mohammed ; Alruwaili, Layth</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c244t-7412dba5566d34c8f2904f4993ff9efa46b8512f424ab3013508c62385e3ccf73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Age groups</topic><topic>Blood</topic><topic>Chronic illnesses</topic><topic>Diabetes</topic><topic>Family medical history</topic><topic>Females</topic><topic>Gender</topic><topic>Hematology</topic><topic>Hemoglobin</topic><topic>Hormones</topic><topic>Hypertension</topic><topic>Hypothyroidism</topic><topic>Iodine</topic><topic>Kidney diseases</topic><topic>Metabolism</topic><topic>Morbidity</topic><topic>Patients</topic><topic>Thyroid diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wani, Farooq A</creatorcontrib><creatorcontrib>Thirunavukkarasu, Ashokkumar</creatorcontrib><creatorcontrib>Alrashed, Hatim</creatorcontrib><creatorcontrib>Alblwan, Abdalrhman S</creatorcontrib><creatorcontrib>Alfuhigi, Yazeed M</creatorcontrib><creatorcontrib>Dilli, Mohammed</creatorcontrib><creatorcontrib>Alruwaili, Layth</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wani, Farooq A</au><au>Thirunavukkarasu, Ashokkumar</au><au>Alrashed, Hatim</au><au>Alblwan, Abdalrhman S</au><au>Alfuhigi, Yazeed M</au><au>Dilli, Mohammed</au><au>Alruwaili, Layth</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Age and Gender-Related Patterns in Clinical Features and Hematological Findings Among Hypothyroidism Patients in the Al-Jouf Region of Saudi Arabia: A Hospital-Based Study</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2024-03-14</date><risdate>2024</risdate><volume>16</volume><issue>3</issue><spage>e56161</spage><epage>e56161</epage><pages>e56161-e56161</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract><![CDATA[The prevalence of hypothyroidism is high in Saudi Arabia and the contributing factors are iodine deficiency and lack of balanced nutrition. This study aims to correlate the gender, age, and presence of co-morbidities with the laboratory findings and clinical presentation.
A cross-sectional study was done in the hospitals of the Al-Jouf region. The files of the patients diagnosed with hypothyroidism from the last two years were retrieved by non-probability consecutive sampling technique. IBM SPSS Statistics for Windows, Version 23, (Released 2015; IBM Corp., Armonk, New York, United States) was used for data entry and analysis. Descriptive statistics were presented as frequencies and proportions (for qualitative variables) and mean and standard deviation (SD) (for continuous data). Associated factors were identified through a chi-square test. A p-value less than 0.05 was considered statistically significant.
Most of the patients were females within the age group of 36 to 50 years. Significant differences were observed between male and female patients with respect to the FT4 levels, hemoglobin (Hb) levels, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) values, and RBC counts (p-values of <0.001, <0.001, <0.001, <0.001, <0.001 and <0.001, respectively). However, no significant differences were observed between male and female patients in the TSH levels and hematocrit values. Most of the patients were euthyroid (77.24%). The pattern of thyroid function status did not show significant differences with respect to the gender of participants and the different age groups (p-values of 0.447 and 0.775, respectively). The most common co-morbidities observed were diabetes and hypertension. No significant association between the co-morbidities and the pattern of thyroid function status was observed. The most common symptoms were epigastric pain, fatigue, constipation, drowsiness, altered bowel habits, and weight gain.
This hospital-based study provides valuable insights into some epidemiological characteristics, clinical features, and hematological findings in hypothyroidism patients of the Al-Jouf region. Significant differences were observed between male and female patients with respect to the FT4 levels, Hb levels, MCV, MCH, MCHC values, and RBC counts. The findings strengthen the existing knowledge base and emphasize the importance of timely detection and management of hypothyroidism in this population. Implementation of salt iodination programs and a timely evaluation of the hematological parameters is recommended. Further research is warranted to delve into the hidden mechanisms and long-term ramifications of hematological changes associated with hypothyroidism.]]></abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>38618448</pmid><doi>10.7759/cureus.56161</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Age groups Blood Chronic illnesses Diabetes Family medical history Females Gender Hematology Hemoglobin Hormones Hypertension Hypothyroidism Iodine Kidney diseases Metabolism Morbidity Patients Thyroid diseases |
| title | Evaluation of Age and Gender-Related Patterns in Clinical Features and Hematological Findings Among Hypothyroidism Patients in the Al-Jouf Region of Saudi Arabia: A Hospital-Based Study |
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