Chemoselective Diazine Dearomatization: The Catalytic Enantioselective Dearomatization of Pyrazine

Despite much progress in the area of dearomatization, the enantioselective dearomatization of heterocycles is limited to those with a single heteroatom. Here we report a highly enantioselective copper-catalyzed dearomatization of pyrazine, a diazine, leading to chiral C-substituted piperazines. When...

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Veröffentlicht in:	Journal of the American Chemical Society 2024-05, Vol.146 (17), p.11610-11615
Hauptverfasser:	Ketelboeter, Devin R., Pappoppula, Mukesh, Aponick, Aaron
Format:	Artikel
Sprache:	eng
Schlagworte:	alkynes catalysts chemical reactions chemoselectivity diastereomers enantioselectivity ligands piperazines pyrazines
Online-Zugang:	Volltext
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