Chemoenzymatic total synthesis of rotigotine via IRED-catalyzed reductive amination

A short and chemoenzymatic synthesis of rotigotine using an IR-36-M5 mutant is reported. Focusing on the residues that directly contact the 2-tetralone moiety, we applied structure-guided semi-rational design to obtain a double-mutant F260W/M147Y, which showed a good isolated yield and -stereoselect...

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Veröffentlicht in:	Organic & biomolecular chemistry 2024-05, Vol.22 (19), p.3843-3847
Hauptverfasser:	Tang, Dongyu, Ma, Yaqing, Bao, Jinping, Gao, Shushan, Man, Shuli, Cui, Chengsen
Format:	Artikel
Sprache:	eng
Schlagworte:	Amination Chemical synthesis Enantiomers Mutants Stereoselectivity
Online-Zugang:	Volltext
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