Chemoenzymatic total synthesis of rotigotine via IRED-catalyzed reductive amination
A short and chemoenzymatic synthesis of rotigotine using an IR-36-M5 mutant is reported. Focusing on the residues that directly contact the 2-tetralone moiety, we applied structure-guided semi-rational design to obtain a double-mutant F260W/M147Y, which showed a good isolated yield and -stereoselect...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2024-05, Vol.22 (19), p.3843-3847 |
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| container_end_page | 3847 |
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| container_issue | 19 |
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| container_title | Organic & biomolecular chemistry |
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| creator | Tang, Dongyu Ma, Yaqing Bao, Jinping Gao, Shushan Man, Shuli Cui, Chengsen |
| description | A short and chemoenzymatic synthesis of rotigotine using an IR-36-M5 mutant is reported. Focusing on the residues that directly contact the 2-tetralone moiety, we applied structure-guided semi-rational design to obtain a double-mutant F260W/M147Y, which showed a good isolated yield and
-stereoselectivity >99% toward 2-aminotetralin synthesis. Furthermore, the utility of this biocatalytic protocol was successfully demonstrated in the enantioselective synthesis of rotigotine
enzymatic reductive amination as the key step. |
| doi_str_mv | 10.1039/d4ob00072b |
| format | Article |
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-stereoselectivity >99% toward 2-aminotetralin synthesis. Furthermore, the utility of this biocatalytic protocol was successfully demonstrated in the enantioselective synthesis of rotigotine
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| ispartof | Organic & biomolecular chemistry, 2024-05, Vol.22 (19), p.3843-3847 |
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| language | eng |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Amination Chemical synthesis Enantiomers Mutants Stereoselectivity |
| title | Chemoenzymatic total synthesis of rotigotine via IRED-catalyzed reductive amination |
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