Acevaltrate promotes apoptosis and inhibits proliferation by suppressing HIF-1α accumulation in cancer cells

•We identified acevaltrate as an inhibitor of hypoxia-inducible factor-1α accumulation from the roots of Valeriana glechomifolia.•Acevaltrate inhibits HIF-1α protein synthesis and promotes degradation of HIF-1α protein.•Acevaltrate inhibits HIF-1α protein expression through suppression of mTOR/p70S6...

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Veröffentlicht in:	International immunopharmacology 2024-05, Vol.133, p.112066-112066, Article 112066
Hauptverfasser:	Mi, Chunliu, Zhang, Qiu-Li, Sun, Meng-Jun, Lv, You, Sun, Qiu-Li, Geng, Shao-Lei, Wang, Tian-Yun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acevaltrate Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use Apoptosis Apoptosis - drug effects Cancer Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line, Tumor Cell Proliferation - drug effects HIF-1α Humans Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Mice Mice, Inbred BALB C Mice, Nude Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Proliferation Ribosomal Protein S6 Kinases, 70-kDa - metabolism TOR Serine-Threonine Kinases - metabolism Valerian - chemistry Xenograft Model Antitumor Assays
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