Ursodeoxycholic acid loaded dual-modified graphene oxide nanocomposite alleviates cholestatic liver injury through inhibiting hepatocyte apoptosis

Ursodeoxycholic acid (UDCA) is the preferred treatment for various types of cholestasis, however, its effectiveness is limited because of its insolubility in water. We used polyethylene glycol (PEG) and cationic polymer polyethylenimine (PEI) to double-modify graphite oxide (PPG) as a drug delivery...

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Veröffentlicht in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2024-06, Vol.238, p.113904-113904, Article 113904
Hauptverfasser:	Zhou, Wanyi, Yang, Xinrui, Yin, Yaru, Chen, Si, Yang, Luxun, Li, Tao, Liu, Jing, Lu, Binghui, Yang, Zhangyou, Li, Rong, Zhang, Mingman
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Autophagy Cholestatic liver injury Graphene oxide Ursodeoxycholic acid
Online-Zugang:	Volltext
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