LAMC1 attenuates neuronal apoptosis via FAK/PI3K/AKT signaling pathway after subarachnoid hemorrhage

The poor prognosis in patients with subarachnoid hemorrhage (SAH) is often attributed to neuronal apoptosis. Recent evidence suggests that Laminin subunit gamma 1 (LAMC1) is essential for cell survival and proliferation. However, the effects of LAMC1 on early brain injury after SAH and the underlyin...

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Veröffentlicht in:	Experimental neurology 2024-06, Vol.376, p.114776-114776, Article 114776
Hauptverfasser:	Wu, Qiaowei, Yuan, Kaikun, Yao, Yanting, Yao, Jinbiao, Shao, Jiang, Meng, Yuxiao, Wu, Pei, Shi, Huaizhang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Disease Models, Animal Early brain injury Focal adhesion kinase Focal Adhesion Kinase 1 - metabolism Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors Focal Adhesion Protein-Tyrosine Kinases - metabolism Laminin - metabolism Laminin subunit gamma 1 Male Mice Neuronal apoptosis Neurons - drug effects Neurons - metabolism Neurons - pathology Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Sprague-Dawley Signal Transduction - drug effects Subarachnoid hemorrhage Subarachnoid Hemorrhage - drug therapy Subarachnoid Hemorrhage - metabolism Subarachnoid Hemorrhage - pathology
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