Neurobiological and Behavioral Underpinnings of Perinatal Mood and Anxiety Disorders (PMADs): A Selective Narrative Review
Perinatal mood and anxiety disorders (PMADs) profoundly impact maternal and infant health, affecting women worldwide during pregnancy and postpartum. This review synthesizes current research on the neurobiological effects of PMADs, particularly their influence on brain structure, function, and corre...
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| Veröffentlicht in: | Journal of clinical medicine 2024-04, Vol.13 (7), p.2088 |
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| creator | Oancea, Mihaela Strilciuc, Ștefan Borza, Dan Boitor Ciortea, Răzvan Diculescu, Doru Mihu, Dan |
| description | Perinatal mood and anxiety disorders (PMADs) profoundly impact maternal and infant health, affecting women worldwide during pregnancy and postpartum. This review synthesizes current research on the neurobiological effects of PMADs, particularly their influence on brain structure, function, and corresponding cognitive, behavioral, and mental health outcomes in mothers. A literature search across PubMed, PsycINFO, and Google Scholar yielded studies utilizing neuroimaging (MRI, fMRI) and cognitive assessments to explore brain changes in PMADs. The key findings indicate significant neurobiological alterations in PMADs, such as glutamatergic dysfunction, neuronal damage, and altered neural connectivity, particularly in postpartum depression (PPD). Functional MRI studies reveal distinct patterns of brain function alteration, including amygdala non-responsivity in PPD, differing from traditional major depressive disorder (MDD). These neurobiological changes are connected with cognitive impairments and behavioral modifications, impacting maternal caregiving. Understanding these alterations is fundamental for developing effective treatments. The findings emphasize the importance of focusing on maternal mental health, advocating for early detection, and personalized treatment strategies to improve maternal and child outcomes. |
| doi_str_mv | 10.3390/jcm13072088 |
| format | Article |
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This review synthesizes current research on the neurobiological effects of PMADs, particularly their influence on brain structure, function, and corresponding cognitive, behavioral, and mental health outcomes in mothers. A literature search across PubMed, PsycINFO, and Google Scholar yielded studies utilizing neuroimaging (MRI, fMRI) and cognitive assessments to explore brain changes in PMADs. The key findings indicate significant neurobiological alterations in PMADs, such as glutamatergic dysfunction, neuronal damage, and altered neural connectivity, particularly in postpartum depression (PPD). Functional MRI studies reveal distinct patterns of brain function alteration, including amygdala non-responsivity in PPD, differing from traditional major depressive disorder (MDD). These neurobiological changes are connected with cognitive impairments and behavioral modifications, impacting maternal caregiving. Understanding these alterations is fundamental for developing effective treatments. The findings emphasize the importance of focusing on maternal mental health, advocating for early detection, and personalized treatment strategies to improve maternal and child outcomes.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm13072088</identifier><identifier>PMID: 38610853</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Affective disorders ; Anxiety ; Anxiety disorders ; Behavior ; Brain research ; Demographic aspects ; Medical examination ; Medical imaging ; Mental depression ; Mental health ; Mothers ; Neurobiology ; Neuroimaging ; Postpartum depression ; Postpartum period ; Pregnancy ; Pregnant women ; Psychological aspects ; Risk factors ; Womens health</subject><ispartof>Journal of clinical medicine, 2024-04, Vol.13 (7), p.2088</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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| subjects | Affective disorders Anxiety Anxiety disorders Behavior Brain research Demographic aspects Medical examination Medical imaging Mental depression Mental health Mothers Neurobiology Neuroimaging Postpartum depression Postpartum period Pregnancy Pregnant women Psychological aspects Risk factors Womens health |
| title | Neurobiological and Behavioral Underpinnings of Perinatal Mood and Anxiety Disorders (PMADs): A Selective Narrative Review |
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