Disruption of sphingomyelin synthase 2 gene alleviates cognitive impairment in a mouse model of Alzheimer’s disease

[Display omitted] •Sphingomyelin synthase 2 (SMS2) gene catalyzes SM synthesis.•3xTg Alzheimer’s model and SMS2 knockout mice were hybridized.•Hybridization alleviated learning deficits and hippocampal hyperexcitability.•Depressive trait was manifested by hybridization.•Hybridization reduced amyloid...

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Veröffentlicht in:	Brain research 2024-07, Vol.1835, p.148934-148934, Article 148934
Hauptverfasser:	Uchiumi, Osamu, Zou, Jingyu, Yamaki, Sachiko, Hori, Yoshie, Ono, Munenori, Yamamoto, Ryo, Kato, Nobuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer’s disease Intracellular amyloid β Membrane raft Sphingomyelin synthase Synaptic plasticity
Online-Zugang:	Volltext
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