Neddylation orchestrates the complex transcriptional and posttranscriptional program that drives Schwann cell myelination

Myelination is essential for neuronal function and health. In peripheral nerves, >100 causative mutations have been identified that cause Charcot-Marie-Tooth disease, a disorder that can affect myelin sheaths. Among these, a number of mutations are related to essential targets of the posttranslat...

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Veröffentlicht in:	Science advances 2024-04, Vol.10 (15), p.eadm7600-eadm7600
Hauptverfasser:	Ayuso-García, Paula, Sánchez-Rueda, Alejandro, Velasco-Avilés, Sergio, Tamayo-Caro, Miguel, Ferrer-Pinós, Aroa, Huarte-Sebastian, Cecilia, Alvarez, Vanesa, Riobello, Cristina, Jiménez-Vega, Selene, Buendia, Izaskun, Cañas-Martin, Jorge, Fernández-Susavila, Héctor, Aparicio-Rey, Adrián, Esquinas-Román, Eva M, Ponte, Carlos Rodríguez, Guhl, Romane, Laville, Nicolas, Pérez-Andrés, Encarni, Lavín, José L, González-Lopez, Monika, Cámara, Nuria Macías, Aransay, Ana M, Lozano, Juan José, Sutherland, James D, Barrio, Rosa, Martinez-Chantar, María Luz, Azkargorta, Mikel, Elortza, Félix, Soriano-Navarro, Mario, Matute, Carlos, Sánchez-Gómez, María Victoria, Bayón-Cordero, Laura, Pérez-Samartín, Alberto, Bravo, Susana B, Kurz, Thimo, Lama-Díaz, Tomas, Blanco, Miguel G, Haddad, Saif, Record, Christopher J, van Hasselt, Peter M, Reilly, Mary M, Varela-Rey, Marta, Woodhoo, Ashwin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Charcot-Marie-Tooth Disease - genetics Mice Mutation Myelin Sheath - genetics Protein Processing, Post-Translational Schwann Cells
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