STAT3 promotes cytoplasmic-nuclear translocation of RNA-binding protein HuR to inhibit IL-1β-induced IL-8 production

•STAT3 inhibition up-regulate IL-1β-induced IL-8.•STAT3 inhibition does not up-regulate IL-1β-induced signaling.•STAT3 inhibition increases the stabilization of IL-8 mRNA.•STAT3 inhibition induces HuR re-localization to cytoplasm.•IL-6 activation of STAT3 induces HuR cytoplasmic-nuclear transport. S...

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Veröffentlicht in:	International immunopharmacology 2024-05, Vol.133, p.112065-112065, Article 112065
Hauptverfasser:	Long, Jiangwen, Zhao, Wang, Xiang, Yangen, Wang, Yufei, Xiang, Wei, Liu, Xueting, Jiang, Manli, Song, Yinghui, Hu, Jinyue
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytoplasmic-nuclear transport HuR IL-1β IL-8 mRNA stabilization STAT3
Online-Zugang:	Volltext
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