Prolonged arthralgias in Whipple’s disease – A common but often overlooked symptom of a rare disease
Whipple’s disease is a multisystemic chronic infectious condition caused by Tropheryma whipplei (T. whipplei). Though characterised often by insidious weight loss, diarrhoea, and arthralgia, three other distinct manifestations can be observed, namely localised disease, acute infection and asymptomat...
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| Veröffentlicht in: | The Journal of the Royal College of Physicians of Edinburgh 2024-03, Vol.54 (1), p.41-43 |
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| container_title | The Journal of the Royal College of Physicians of Edinburgh |
| container_volume | 54 |
| creator | Canhão, Bernardo Tourais Trigo, André Madeira, Joana Inês Simão, Adélia Madaleno, João |
| description | Whipple’s disease is a multisystemic chronic infectious condition caused by Tropheryma whipplei (T. whipplei). Though characterised often by insidious weight loss, diarrhoea, and arthralgia, three other distinct manifestations can be observed, namely localised disease, acute infection and asymptomatic carriage. The diagnosis relies on histopathological examination of duodenal biopsies and polymerase chain reaction analysis of the 16S rRNA gene for T. whipplei. We report the case of a middle-aged man admitted for etiologic investigation of prolonged, migrating, and inflammatory arthralgias and subsequent development of gastrointestinal symptoms. Despite its reputation as a great mimicker of many different illnesses, the difficulty in diagnosis probably lies with its rarity rather than its masking. |
| doi_str_mv | 10.1177/14782715241237283 |
| format | Article |
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| ispartof | The Journal of the Royal College of Physicians of Edinburgh, 2024-03, Vol.54 (1), p.41-43 |
| issn | 1478-2715 2042-8189 |
| language | eng |
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| source | MEDLINE; SAGE Complete; Alma/SFX Local Collection |
| subjects | Anti-Bacterial Agents - therapeutic use Biopsy Humans Male Middle Aged Rare Diseases RNA, Ribosomal, 16S - genetics Whipple Disease - complications Whipple Disease - diagnosis Whipple Disease - drug therapy |
| title | Prolonged arthralgias in Whipple’s disease – A common but often overlooked symptom of a rare disease |
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