Pinobanksin ameliorated DSS-induced acute colitis mainly through modulation of SLC7A11/glutathione-mediated intestinal epithelial ferroptosis

Inhibition of ferroptosis in intestinal epithelial cells serves as an attractive target for the development of therapeutic strategies for colitis. Pinobanksin, one of the main flavonoids derived from propolis, possesses significant anti-inflammatory effects and inhibits the cell death of several cel...

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Veröffentlicht in:	Food & function 2024-05, Vol.15 (9), p.497-4982
Hauptverfasser:	Bi, Hailian, Guo, Shibin, Wang, Yan, Liu, Zhijie, Wu, Guokai, Huo, Xiaokui, Guo, Li, Guo, Huishu, Xiong, Yongjian
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Transport System y+ - genetics Amino Acid Transport System y+ - metabolism Animal tissues Animals Biosynthesis Cell activation Cell death Cell lines Cells Colitis Colitis - chemically induced Colitis - drug therapy Colitis - metabolism Cystine Dextran Sulfate - adverse effects Disease Models, Animal Distilled water Epithelial cells Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelium Ferroptosis Ferroptosis - drug effects Flavonoids Flavonoids - pharmacology Glutathione Glutathione - metabolism Humans Inflammation Inflammatory bowel disease Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestine Lipid peroxidation Lipids Male Mice Mice, Inbred C57BL Modulation Peroxidation Phospholipid Hydroperoxide Glutathione Peroxidase - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Ribonucleic acid RNA
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