Differential contributions of G protein‐ or arrestin subtype‐mediated signalling underlie urocortin 3‐induced somatostatin secretion in pancreatic δ cells

Background and Purpose Pancreatic islets are modulated by cross‐talk among different cell types and paracrine signalling plays important roles in maintaining glucose homeostasis. Urocortin 3 (UCN3) secreted by pancreatic β cells activates the CRF2 receptor (CRF2R) and downstream pathways mediated by...

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Veröffentlicht in:	British journal of pharmacology 2024-08, Vol.181 (15), p.2600-2621
Hauptverfasser:	Wang, Kai‐Yu, Gao, Ming‐Xin, Qi, Hai‐Bo, An, Wen‐tao, Lin, Jing‐Yu, Ning, Shang‐Lei, Yang, Fan, Xiao, Peng, Cheng, Jie, Pan, Wei, Cheng, Qiu‐xia, Wang, Jin, Fang, Le, Sun, Jin‐Peng, Yu, Xiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arrestin Beta cells CRF2 receptor Glucose GTP-Binding Proteins - metabolism Homeostasis Male Mice Mice, Inbred C57BL Mice, Knockout Pancreas pancreatic δ cell Paracrine signalling Phosphorylation Proteins Receptors, Corticotropin-Releasing Hormone - metabolism Ryanodine receptors Secretion Signal Transduction signalling pathway Somatostatin Somatostatin - metabolism somatostatin secretion Somatostatin-Secreting Cells - metabolism Stat6 protein UCN3 Urocortin Urocortins - metabolism
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