Probing the Mechanisms Underlying the Transport of the Vinca Alkaloids by P-glycoprotein

The efficacy of many cancer drugs is hindered by P-glycoprotein (Pgp), a cellular pump that removes drugs from cells. To improve chemotherapy, drugs capable of evading Pgp must be developed. Despite similarities in structure, vinca alkaloids (VAs) show disparate Pgp-mediated efflux ratios. ATPase ac...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2024-07, Vol.113 (7), p.1960-1974
Hauptverfasser:	Mensah, Gershon A.K., Schaefer, Katherine G., Roberts, Arthur G., King, Gavin M., Bartlett, Michael G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Atomic force microscopy Fluorescence spectroscopy NMR p-glycoprotein Vinca alkaloids
Online-Zugang:	Volltext
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