Function and mechanism exploring of icariin in schizophrenia through network pharmacology
[Display omitted] •Icariin can improve the spatial learning and memory abilities of schizophrenic rats.•Icariin can decrease the oxidative stress and inflammatory response levels of schizophrenic rats.•MAPK1, MAPK3, FOS, RELA, TNF, and JUN are the core targets for icariin in treatment of schizophren...
Gespeichert in:
| Veröffentlicht in: | Brain research 2024-07, Vol.1835, p.148931-148931, Article 148931 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 148931 |
|---|---|
| container_issue | |
| container_start_page | 148931 |
| container_title | Brain research |
| container_volume | 1835 |
| creator | Liu, Bing Wang, Chengqiang Liu, Ruyuan Xiang, Weilai Yang, Chang Li, Di |
| description | [Display omitted]
•Icariin can improve the spatial learning and memory abilities of schizophrenic rats.•Icariin can decrease the oxidative stress and inflammatory response levels of schizophrenic rats.•MAPK1, MAPK3, FOS, RELA, TNF, and JUN are the core targets for icariin in treatment of schizophrenia.
This study aims to explore the therapeutic effect and possible mechanisms of icariin in schizophrenia. SD rats were divided into five groups, a control group, a MK801-induced schizophrenia model group, and three icariin treatment groups, with twelve rats in each group. Morris water maze and open field were used to observe the spatial learning and memory ability of rats. Compared with the control group, rats in the MK801-induced model group showed an increase in stereotypic behavior score, distance of spontaneous activities, escape latency, malondialdehyde (MDA) content, and IL-6, IL-1β, TNF-α expression, but a decrease in platform crossing times and superoxide dismutase (SOD) activity (P |
| doi_str_mv | 10.1016/j.brainres.2024.148931 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3038428093</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006899324001859</els_id><sourcerecordid>3038428093</sourcerecordid><originalsourceid>FETCH-LOGICAL-c315t-11283a6c734b703c553d57fd27f835a82b835cbf05459ccb8f76ea0a31706a863</originalsourceid><addsrcrecordid>eNqFkE9LxDAQxYMouv75CpKjl65J06TpTVlcFQQvevAU0nS6zdomNWnV9dNbWderMPAYeG8e80PonJI5JVRcrudl0NYFiPOUpNmcZrJgdA_NqMzTRKQZ2UczQohIZFGwI3Qc43paGSvIITpiUpCMcz5DL8vRmcF6h7WrcAem0c7GDsNn3_pg3Qr7Glujg7UOTxNNY7983wRwVuOhCX5cNdjB8OHDK-4bHTptfOtXm1N0UOs2wtmvnqDn5c3T4i55eLy9X1w_JIZRPiSUppJpYXKWlTlhhnNW8byu0ryWjGuZlpOYsiY844UxpaxzAZpoRnMitBTsBF1s7_bBv40QB9XZaKBttQM_RsUIk1kqScEmq9haTfAxBqhVH2ynw0ZRon6wqrXaYVU_WNUW6xQ8_-0Yyw6qv9iO42S42hpg-vTdQlDRWHAGKhvADKry9r-Ob4ZFjWI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3038428093</pqid></control><display><type>article</type><title>Function and mechanism exploring of icariin in schizophrenia through network pharmacology</title><source>Elsevier ScienceDirect Journals</source><creator>Liu, Bing ; Wang, Chengqiang ; Liu, Ruyuan ; Xiang, Weilai ; Yang, Chang ; Li, Di</creator><creatorcontrib>Liu, Bing ; Wang, Chengqiang ; Liu, Ruyuan ; Xiang, Weilai ; Yang, Chang ; Li, Di</creatorcontrib><description>[Display omitted]
•Icariin can improve the spatial learning and memory abilities of schizophrenic rats.•Icariin can decrease the oxidative stress and inflammatory response levels of schizophrenic rats.•MAPK1, MAPK3, FOS, RELA, TNF, and JUN are the core targets for icariin in treatment of schizophrenia.
This study aims to explore the therapeutic effect and possible mechanisms of icariin in schizophrenia. SD rats were divided into five groups, a control group, a MK801-induced schizophrenia model group, and three icariin treatment groups, with twelve rats in each group. Morris water maze and open field were used to observe the spatial learning and memory ability of rats. Compared with the control group, rats in the MK801-induced model group showed an increase in stereotypic behavior score, distance of spontaneous activities, escape latency, malondialdehyde (MDA) content, and IL-6, IL-1β, TNF-α expression, but a decrease in platform crossing times and superoxide dismutase (SOD) activity (P < 0.05). Furthermore, all the above changes of the model group were reversed after icariin treatment in a dose-dependent manner (P < 0.05). Network pharmacology found that icariin can exert anti-schizophrenic effects through some signaling pathways, such as relaxin, estrogen, and TNF signaling pathways. MAPK1, MAPK3, FOS, RELA, TNF, and JUN were the key targets of icariin on schizophrenia, and their expression was detected in animal models, which was consistent with the predicted results of network pharmacology. Icariin treatment may improve the spatial learning and memory ability of schizophrenic rats through TNF signaling pathway.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/j.brainres.2024.148931</identifier><identifier>PMID: 38604555</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Icariin ; Network pharmacology ; Schizophrenia ; Spatial learning and memory ability ; TNF</subject><ispartof>Brain research, 2024-07, Vol.1835, p.148931-148931, Article 148931</ispartof><rights>2024</rights><rights>Copyright © 2024. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c315t-11283a6c734b703c553d57fd27f835a82b835cbf05459ccb8f76ea0a31706a863</cites><orcidid>0009-0008-3668-560X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006899324001859$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38604555$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Bing</creatorcontrib><creatorcontrib>Wang, Chengqiang</creatorcontrib><creatorcontrib>Liu, Ruyuan</creatorcontrib><creatorcontrib>Xiang, Weilai</creatorcontrib><creatorcontrib>Yang, Chang</creatorcontrib><creatorcontrib>Li, Di</creatorcontrib><title>Function and mechanism exploring of icariin in schizophrenia through network pharmacology</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>[Display omitted]
•Icariin can improve the spatial learning and memory abilities of schizophrenic rats.•Icariin can decrease the oxidative stress and inflammatory response levels of schizophrenic rats.•MAPK1, MAPK3, FOS, RELA, TNF, and JUN are the core targets for icariin in treatment of schizophrenia.
This study aims to explore the therapeutic effect and possible mechanisms of icariin in schizophrenia. SD rats were divided into five groups, a control group, a MK801-induced schizophrenia model group, and three icariin treatment groups, with twelve rats in each group. Morris water maze and open field were used to observe the spatial learning and memory ability of rats. Compared with the control group, rats in the MK801-induced model group showed an increase in stereotypic behavior score, distance of spontaneous activities, escape latency, malondialdehyde (MDA) content, and IL-6, IL-1β, TNF-α expression, but a decrease in platform crossing times and superoxide dismutase (SOD) activity (P < 0.05). Furthermore, all the above changes of the model group were reversed after icariin treatment in a dose-dependent manner (P < 0.05). Network pharmacology found that icariin can exert anti-schizophrenic effects through some signaling pathways, such as relaxin, estrogen, and TNF signaling pathways. MAPK1, MAPK3, FOS, RELA, TNF, and JUN were the key targets of icariin on schizophrenia, and their expression was detected in animal models, which was consistent with the predicted results of network pharmacology. Icariin treatment may improve the spatial learning and memory ability of schizophrenic rats through TNF signaling pathway.</description><subject>Icariin</subject><subject>Network pharmacology</subject><subject>Schizophrenia</subject><subject>Spatial learning and memory ability</subject><subject>TNF</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkE9LxDAQxYMouv75CpKjl65J06TpTVlcFQQvevAU0nS6zdomNWnV9dNbWderMPAYeG8e80PonJI5JVRcrudl0NYFiPOUpNmcZrJgdA_NqMzTRKQZ2UczQohIZFGwI3Qc43paGSvIITpiUpCMcz5DL8vRmcF6h7WrcAem0c7GDsNn3_pg3Qr7Glujg7UOTxNNY7983wRwVuOhCX5cNdjB8OHDK-4bHTptfOtXm1N0UOs2wtmvnqDn5c3T4i55eLy9X1w_JIZRPiSUppJpYXKWlTlhhnNW8byu0ryWjGuZlpOYsiY844UxpaxzAZpoRnMitBTsBF1s7_bBv40QB9XZaKBttQM_RsUIk1kqScEmq9haTfAxBqhVH2ynw0ZRon6wqrXaYVU_WNUW6xQ8_-0Yyw6qv9iO42S42hpg-vTdQlDRWHAGKhvADKry9r-Ob4ZFjWI</recordid><startdate>20240715</startdate><enddate>20240715</enddate><creator>Liu, Bing</creator><creator>Wang, Chengqiang</creator><creator>Liu, Ruyuan</creator><creator>Xiang, Weilai</creator><creator>Yang, Chang</creator><creator>Li, Di</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0009-0008-3668-560X</orcidid></search><sort><creationdate>20240715</creationdate><title>Function and mechanism exploring of icariin in schizophrenia through network pharmacology</title><author>Liu, Bing ; Wang, Chengqiang ; Liu, Ruyuan ; Xiang, Weilai ; Yang, Chang ; Li, Di</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-11283a6c734b703c553d57fd27f835a82b835cbf05459ccb8f76ea0a31706a863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Icariin</topic><topic>Network pharmacology</topic><topic>Schizophrenia</topic><topic>Spatial learning and memory ability</topic><topic>TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Bing</creatorcontrib><creatorcontrib>Wang, Chengqiang</creatorcontrib><creatorcontrib>Liu, Ruyuan</creatorcontrib><creatorcontrib>Xiang, Weilai</creatorcontrib><creatorcontrib>Yang, Chang</creatorcontrib><creatorcontrib>Li, Di</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Bing</au><au>Wang, Chengqiang</au><au>Liu, Ruyuan</au><au>Xiang, Weilai</au><au>Yang, Chang</au><au>Li, Di</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Function and mechanism exploring of icariin in schizophrenia through network pharmacology</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2024-07-15</date><risdate>2024</risdate><volume>1835</volume><spage>148931</spage><epage>148931</epage><pages>148931-148931</pages><artnum>148931</artnum><issn>0006-8993</issn><eissn>1872-6240</eissn><abstract>[Display omitted]
•Icariin can improve the spatial learning and memory abilities of schizophrenic rats.•Icariin can decrease the oxidative stress and inflammatory response levels of schizophrenic rats.•MAPK1, MAPK3, FOS, RELA, TNF, and JUN are the core targets for icariin in treatment of schizophrenia.
This study aims to explore the therapeutic effect and possible mechanisms of icariin in schizophrenia. SD rats were divided into five groups, a control group, a MK801-induced schizophrenia model group, and three icariin treatment groups, with twelve rats in each group. Morris water maze and open field were used to observe the spatial learning and memory ability of rats. Compared with the control group, rats in the MK801-induced model group showed an increase in stereotypic behavior score, distance of spontaneous activities, escape latency, malondialdehyde (MDA) content, and IL-6, IL-1β, TNF-α expression, but a decrease in platform crossing times and superoxide dismutase (SOD) activity (P < 0.05). Furthermore, all the above changes of the model group were reversed after icariin treatment in a dose-dependent manner (P < 0.05). Network pharmacology found that icariin can exert anti-schizophrenic effects through some signaling pathways, such as relaxin, estrogen, and TNF signaling pathways. MAPK1, MAPK3, FOS, RELA, TNF, and JUN were the key targets of icariin on schizophrenia, and their expression was detected in animal models, which was consistent with the predicted results of network pharmacology. Icariin treatment may improve the spatial learning and memory ability of schizophrenic rats through TNF signaling pathway.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>38604555</pmid><doi>10.1016/j.brainres.2024.148931</doi><tpages>1</tpages><orcidid>https://orcid.org/0009-0008-3668-560X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-8993 |
| ispartof | Brain research, 2024-07, Vol.1835, p.148931-148931, Article 148931 |
| issn | 0006-8993 1872-6240 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3038428093 |
| source | Elsevier ScienceDirect Journals |
| subjects | Icariin Network pharmacology Schizophrenia Spatial learning and memory ability TNF |
| title | Function and mechanism exploring of icariin in schizophrenia through network pharmacology |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T04%3A33%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Function%20and%20mechanism%20exploring%20of%20icariin%20in%20schizophrenia%20through%20network%20pharmacology&rft.jtitle=Brain%20research&rft.au=Liu,%20Bing&rft.date=2024-07-15&rft.volume=1835&rft.spage=148931&rft.epage=148931&rft.pages=148931-148931&rft.artnum=148931&rft.issn=0006-8993&rft.eissn=1872-6240&rft_id=info:doi/10.1016/j.brainres.2024.148931&rft_dat=%3Cproquest_cross%3E3038428093%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3038428093&rft_id=info:pmid/38604555&rft_els_id=S0006899324001859&rfr_iscdi=true |