Design, Synthesis, and Biological Evaluation of Novel Arylomycins against Multidrug-Resistant Gram-Negative Bacteria

G0775, an arylomycin-type SPase I inhibitor that is being evaluated in a preclinical study, exhibited potent antibacterial activities against some Gram-negative bacteria but meanwhile suffered defects such as a narrow antibacterial spectrum and poor pharmacokinetic properties. Herein, systematic str...

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Veröffentlicht in:	Journal of medicinal chemistry 2024-04, Vol.67 (8), p.6585-6609
Hauptverfasser:	Zhang, Yinyong, Zhang, Dan, Zhao, Wenhao, Li, Hongyuan, Lu, Zhengyu, Guo, Bin, Meng, Xin, Zhou, Xianli, Yang, Yushe
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinetobacter baumannii - drug effects Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Drug Design Drug Resistance, Multiple, Bacterial - drug effects Gram-Negative Bacteria - drug effects Male Mice Microbial Sensitivity Tests Pseudomonas aeruginosa - drug effects Rats Structure-Activity Relationship
Online-Zugang:	Volltext
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