Targeted ferritinophagy in gastrointestinal cancer: from molecular mechanisms to implications
Gastrointestinal cancer is a significant global health burden, necessitating the development of novel therapeutic strategies. Emerging evidence has highlighted the potential of targeting ferritinophagy as a promising approach for the treatment of gastrointestinal cancer. Ferritinophagy is a form of...
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| Veröffentlicht in: | Archives of toxicology 2024-07, Vol.98 (7), p.2007-2018 |
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| container_end_page | 2018 |
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| container_issue | 7 |
| container_start_page | 2007 |
| container_title | Archives of toxicology |
| container_volume | 98 |
| creator | Feng, Zhaotian Luan, Muhua Zhu, Wenshuai Xing, Yuanxin Ma, Xiaoli Wang, Yunshan Jia, Yanfei |
| description | Gastrointestinal cancer is a significant global health burden, necessitating the development of novel therapeutic strategies. Emerging evidence has highlighted the potential of targeting ferritinophagy as a promising approach for the treatment of gastrointestinal cancer. Ferritinophagy is a form of selective autophagy that is mediated by the nuclear receptor coactivator 4 (NCOA4). This process plays a crucial role in regulating cellular iron homeostasis and has been implicated in various pathological conditions, including cancer. This review discusses the molecular mechanisms underlying ferritinophagy and its relevance to gastrointestinal cancer. Furthermore, we highlight the potential therapeutic implications of targeting ferritinophagy in gastrointestinal cancer. Several approaches have been proposed to modulate ferritinophagy, including small molecule inhibitors and immunotherapeutic strategies. We discuss the advantages and challenges associated with these therapeutic interventions and provide insights into their potential clinical applications. |
| doi_str_mv | 10.1007/s00204-024-03745-y |
| format | Article |
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| subjects | Animals Archives & records Autophagy Autophagy - drug effects Biomedical and Life Sciences Biomedicine Cancer Cell death Environmental Health Ferritins - metabolism Ferroptosis Gastrointestinal cancer gastrointestinal neoplasms Gastrointestinal Neoplasms - drug therapy Gastrointestinal Neoplasms - metabolism Global health Homeostasis Humans immunotherapy Iron - metabolism Lipid peroxidation Lipids Medical prognosis Molecular modelling Nuclear Receptor Coactivators - metabolism Occupational Medicine/Industrial Medicine Pharmacology/Toxicology Proteins Public health Review Article Therapeutic applications Toxicology Tumors |
| title | Targeted ferritinophagy in gastrointestinal cancer: from molecular mechanisms to implications |
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