The Impact of Cannabis Use on Cognition in People with HIV: Evidence of Function-Dependent Effects and Mechanisms from Clinical and Preclinical Studies
Purpose of Review Cannabis may have beneficial anti-inflammatory effects in people with HIV (PWH); however, given this population’s high burden of persisting neurocognitive impairment (NCI), clinicians are concerned they may be particularly vulnerable to the deleterious effects of cannabis on cognit...
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| Veröffentlicht in: | Current HIV/AIDS reports 2024-06, Vol.21 (3), p.87-115 |
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| creator | Ayoub, Samantha M. Holloway, Breanna M. Miranda, Alannah H. Roberts, Benjamin Z. Young, Jared W. Minassian, Arpi Ellis, Ronald J. |
| description | Purpose of Review
Cannabis may have beneficial anti-inflammatory effects in people with HIV (PWH); however, given this population’s high burden of persisting neurocognitive impairment (NCI), clinicians are concerned they may be particularly vulnerable to the deleterious effects of cannabis on cognition. Here, we present a systematic scoping review of clinical and preclinical studies evaluating the effects of cannabinoid exposure on cognition in HIV.
Recent Findings
Results revealed little evidence to support a harmful impact of cannabis use on cognition in HIV, with few eligible preclinical data existing. Furthermore, the beneficial/harmful effects of cannabis use observed on cognition were function-dependent and confounded by several factors (e.g., age, frequency of use).
Summary
Results are discussed alongside potential mechanisms of cannabis effects on cognition in HIV (e.g., anti-inflammatory), and considerations are outlined for screening PWH that may benefit from cannabis interventions. We further highlight the value of accelerating research discoveries in this area by utilizing translatable cross-species tasks to facilitate comparisons across human and animal work. |
| doi_str_mv | 10.1007/s11904-024-00698-w |
| format | Article |
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Cannabis may have beneficial anti-inflammatory effects in people with HIV (PWH); however, given this population’s high burden of persisting neurocognitive impairment (NCI), clinicians are concerned they may be particularly vulnerable to the deleterious effects of cannabis on cognition. Here, we present a systematic scoping review of clinical and preclinical studies evaluating the effects of cannabinoid exposure on cognition in HIV.
Recent Findings
Results revealed little evidence to support a harmful impact of cannabis use on cognition in HIV, with few eligible preclinical data existing. Furthermore, the beneficial/harmful effects of cannabis use observed on cognition were function-dependent and confounded by several factors (e.g., age, frequency of use).
Summary
Results are discussed alongside potential mechanisms of cannabis effects on cognition in HIV (e.g., anti-inflammatory), and considerations are outlined for screening PWH that may benefit from cannabis interventions. We further highlight the value of accelerating research discoveries in this area by utilizing translatable cross-species tasks to facilitate comparisons across human and animal work.</description><identifier>ISSN: 1548-3568</identifier><identifier>ISSN: 1548-3576</identifier><identifier>EISSN: 1548-3576</identifier><identifier>DOI: 10.1007/s11904-024-00698-w</identifier><identifier>PMID: 38602558</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Cannabinoids - adverse effects ; Cannabinoids - pharmacology ; Cannabinoids - therapeutic use ; Cannabis ; Cannabis - adverse effects ; Cognition ; Cognition & reasoning ; Cognition - drug effects ; Cognitive Dysfunction - drug therapy ; Cognitive Dysfunction - etiology ; HIV ; HIV Infections - complications ; HIV Infections - drug therapy ; HIV Infections - psychology ; Human immunodeficiency virus ; Humans ; Inflammation ; Marijuana ; Marijuana Use - adverse effects ; Medicine ; Medicine & Public Health ; Review ; Topical Collection on Central Nervous System and Cognition</subject><ispartof>Current HIV/AIDS reports, 2024-06, Vol.21 (3), p.87-115</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-18da572384f482b7ab6e9b12c6a2966e6be1c8526155c80abe83e842b11e532d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11904-024-00698-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11904-024-00698-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38602558$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ayoub, Samantha M.</creatorcontrib><creatorcontrib>Holloway, Breanna M.</creatorcontrib><creatorcontrib>Miranda, Alannah H.</creatorcontrib><creatorcontrib>Roberts, Benjamin Z.</creatorcontrib><creatorcontrib>Young, Jared W.</creatorcontrib><creatorcontrib>Minassian, Arpi</creatorcontrib><creatorcontrib>Ellis, Ronald J.</creatorcontrib><title>The Impact of Cannabis Use on Cognition in People with HIV: Evidence of Function-Dependent Effects and Mechanisms from Clinical and Preclinical Studies</title><title>Current HIV/AIDS reports</title><addtitle>Curr HIV/AIDS Rep</addtitle><addtitle>Curr HIV/AIDS Rep</addtitle><description>Purpose of Review
Cannabis may have beneficial anti-inflammatory effects in people with HIV (PWH); however, given this population’s high burden of persisting neurocognitive impairment (NCI), clinicians are concerned they may be particularly vulnerable to the deleterious effects of cannabis on cognition. Here, we present a systematic scoping review of clinical and preclinical studies evaluating the effects of cannabinoid exposure on cognition in HIV.
Recent Findings
Results revealed little evidence to support a harmful impact of cannabis use on cognition in HIV, with few eligible preclinical data existing. Furthermore, the beneficial/harmful effects of cannabis use observed on cognition were function-dependent and confounded by several factors (e.g., age, frequency of use).
Summary
Results are discussed alongside potential mechanisms of cannabis effects on cognition in HIV (e.g., anti-inflammatory), and considerations are outlined for screening PWH that may benefit from cannabis interventions. We further highlight the value of accelerating research discoveries in this area by utilizing translatable cross-species tasks to facilitate comparisons across human and animal work.</description><subject>Animals</subject><subject>Cannabinoids - adverse effects</subject><subject>Cannabinoids - pharmacology</subject><subject>Cannabinoids - therapeutic use</subject><subject>Cannabis</subject><subject>Cannabis - adverse effects</subject><subject>Cognition</subject><subject>Cognition & reasoning</subject><subject>Cognition - drug effects</subject><subject>Cognitive Dysfunction - drug therapy</subject><subject>Cognitive Dysfunction - etiology</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - psychology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Marijuana</subject><subject>Marijuana Use - adverse effects</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Review</subject><subject>Topical Collection on Central Nervous System and Cognition</subject><issn>1548-3568</issn><issn>1548-3576</issn><issn>1548-3576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS1E1ZbSF2CBLLFhE-qf2HHYoXRKRyqiEi1by3FuOq4SO9gJI56E18XTaYvEgoXle32_c2z5IPSGkg-UkOosUVqTsiAsLyJrVWxfoGMqSlVwUcmXz7VUR-hVSveE8LIu5SE64koSJoQ6Rr9vNoDX42TsjEOPG-O9aV3Ctwlw8LgJd97NLlfO42sI0wB46-YNvlx__4hXP10H3sJOebF4uwOLc5jA5-MZr_oe7Jyw8R3-AnZjvEtjwn0MI24G5501w8PwOoJ96r_NS-cgvUYHvRkSnD7uJ-j2YnXTXBZXXz-vm09XheVMzgVVnREV46rsS8XayrQS6pYyKw2rpQTZArVKMEmFsIqYFhQHVbKWUhCcdfwEvd_7TjH8WCDNenTJwjAYD2FJmhNe8VqUnGb03T_ofViiz6_LlCRVTfK3ZortKRtDShF6PUU3mvhLU6J3sel9bDrHph9i09ssevtovbQjdM-Sp5wywPdAyiN_B_Hv3f-x_QOhsaMo</recordid><startdate>20240601</startdate><enddate>20240601</enddate><creator>Ayoub, Samantha M.</creator><creator>Holloway, Breanna M.</creator><creator>Miranda, Alannah H.</creator><creator>Roberts, Benjamin Z.</creator><creator>Young, Jared W.</creator><creator>Minassian, Arpi</creator><creator>Ellis, Ronald J.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240601</creationdate><title>The Impact of Cannabis Use on Cognition in People with HIV: Evidence of Function-Dependent Effects and Mechanisms from Clinical and Preclinical Studies</title><author>Ayoub, Samantha M. ; Holloway, Breanna M. ; Miranda, Alannah H. ; Roberts, Benjamin Z. ; Young, Jared W. ; Minassian, Arpi ; Ellis, Ronald J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-18da572384f482b7ab6e9b12c6a2966e6be1c8526155c80abe83e842b11e532d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Cannabinoids - adverse effects</topic><topic>Cannabinoids - pharmacology</topic><topic>Cannabinoids - therapeutic use</topic><topic>Cannabis</topic><topic>Cannabis - adverse effects</topic><topic>Cognition</topic><topic>Cognition & reasoning</topic><topic>Cognition - drug effects</topic><topic>Cognitive Dysfunction - drug therapy</topic><topic>Cognitive Dysfunction - etiology</topic><topic>HIV</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - psychology</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Marijuana</topic><topic>Marijuana Use - adverse effects</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Review</topic><topic>Topical Collection on Central Nervous System and Cognition</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ayoub, Samantha M.</creatorcontrib><creatorcontrib>Holloway, Breanna M.</creatorcontrib><creatorcontrib>Miranda, Alannah H.</creatorcontrib><creatorcontrib>Roberts, Benjamin Z.</creatorcontrib><creatorcontrib>Young, Jared W.</creatorcontrib><creatorcontrib>Minassian, Arpi</creatorcontrib><creatorcontrib>Ellis, Ronald J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current HIV/AIDS reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ayoub, Samantha M.</au><au>Holloway, Breanna M.</au><au>Miranda, Alannah H.</au><au>Roberts, Benjamin Z.</au><au>Young, Jared W.</au><au>Minassian, Arpi</au><au>Ellis, Ronald J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Impact of Cannabis Use on Cognition in People with HIV: Evidence of Function-Dependent Effects and Mechanisms from Clinical and Preclinical Studies</atitle><jtitle>Current HIV/AIDS reports</jtitle><stitle>Curr HIV/AIDS Rep</stitle><addtitle>Curr HIV/AIDS Rep</addtitle><date>2024-06-01</date><risdate>2024</risdate><volume>21</volume><issue>3</issue><spage>87</spage><epage>115</epage><pages>87-115</pages><issn>1548-3568</issn><issn>1548-3576</issn><eissn>1548-3576</eissn><abstract>Purpose of Review
Cannabis may have beneficial anti-inflammatory effects in people with HIV (PWH); however, given this population’s high burden of persisting neurocognitive impairment (NCI), clinicians are concerned they may be particularly vulnerable to the deleterious effects of cannabis on cognition. Here, we present a systematic scoping review of clinical and preclinical studies evaluating the effects of cannabinoid exposure on cognition in HIV.
Recent Findings
Results revealed little evidence to support a harmful impact of cannabis use on cognition in HIV, with few eligible preclinical data existing. Furthermore, the beneficial/harmful effects of cannabis use observed on cognition were function-dependent and confounded by several factors (e.g., age, frequency of use).
Summary
Results are discussed alongside potential mechanisms of cannabis effects on cognition in HIV (e.g., anti-inflammatory), and considerations are outlined for screening PWH that may benefit from cannabis interventions. We further highlight the value of accelerating research discoveries in this area by utilizing translatable cross-species tasks to facilitate comparisons across human and animal work.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>38602558</pmid><doi>10.1007/s11904-024-00698-w</doi><tpages>29</tpages></addata></record> |
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| subjects | Animals Cannabinoids - adverse effects Cannabinoids - pharmacology Cannabinoids - therapeutic use Cannabis Cannabis - adverse effects Cognition Cognition & reasoning Cognition - drug effects Cognitive Dysfunction - drug therapy Cognitive Dysfunction - etiology HIV HIV Infections - complications HIV Infections - drug therapy HIV Infections - psychology Human immunodeficiency virus Humans Inflammation Marijuana Marijuana Use - adverse effects Medicine Medicine & Public Health Review Topical Collection on Central Nervous System and Cognition |
| title | The Impact of Cannabis Use on Cognition in People with HIV: Evidence of Function-Dependent Effects and Mechanisms from Clinical and Preclinical Studies |
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