3,3′-Diindolylmethane inhibits Th17 cell differentiation via impairing IRF-7-mediated plasmacytoid dendritic cell activation in imiquimod-induced psoriasis mice

Psoriasis is a paradigmatic condition characterised by a heightened autoimmune response and chronic inflammation. However, the exact nature and the pathological causes behind it are still unknown. Growing evidence suggest dysregulated cytokine network as a result of over-activated T cells and plasma...

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Veröffentlicht in:	In vitro cellular & developmental biology. Animal 2024-06, Vol.60 (6), p.678-688
Hauptverfasser:	Rasool, Mahaboobkhan, Srikanth, Manupati, Rithvik, Arulkumaran
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation analysis Aminoquinolines - pharmacology Animal Genetics and Genomics Animals Antiviral drugs Autoimmune diseases autoimmunity Biomedical and Life Sciences Cell activation Cell Biology Cell Culture Cell differentiation Cell Differentiation - drug effects Cell signaling Chronic illnesses Cytokines Cytokines - metabolism Dendritic cells Dendritic Cells - drug effects Dendritic Cells - metabolism Developmental Biology Differentiation (biology) Gene expression Helper cells Imiquimod Immunotherapy Indoles - pharmacology Inflammation Interferon regulatory factor 7 Interferon Regulatory Factors - genetics Interferon Regulatory Factors - metabolism interleukin-17 interleukin-23 interleukin-6 Life Sciences Lymphocytes Lymphocytes T Mice Pathogens Psoriasis Psoriasis - chemically induced Psoriasis - drug therapy Psoriasis - pathology Skin diseases Stem Cells Th17 Cells - drug effects therapeutics Transcription activation Transcription factors α-Interferon
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