The effect of food on the pharmacokinetics of Sutetinib maleate capsule, an irreversible EGFR tyrosine kinase inhibitor, in healthy Chinese subjects

Sutetinib is an irreversible inhibitor of epidermal growth factor receptor (EGFR) and showed favorable efficacy and safety in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) harbouring nondrug-resistant rare EGFR mutations. To evaluate the potential food effect, eight...

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Veröffentlicht in:	Investigational new drugs 2024-06, Vol.42 (3), p.289-298
Hauptverfasser:	Cao, Bei, Ma, Tingting, Zhang, Yuqiang, Huang, Lei, Lin, Hui, Jiang, Huanhuan, Zhao, Yu, Geng, Yan, Yang, Yuanxun, Cao, Sumin, Li, Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adverse events Asian People Capsules Clinical trials Cross-Over Studies East Asian People Epidermal growth factor receptors ErbB Receptors - antagonists & inhibitors ErbB Receptors - genetics Fasting Female Food Food intake Food-Drug Interactions Growth factors Healthy Volunteers High fat diet Humans Kinases Liquid chromatography Lung cancer Male Mass spectrometry Mass spectroscopy Medicine Medicine & Public Health Metabolites Metastases Middle Aged Non-small cell lung carcinoma Oncology Pharmacokinetics Pharmacology/Toxicology Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - adverse effects Protein Kinase Inhibitors - blood Protein Kinase Inhibitors - pharmacokinetics Registration Small cell lung carcinoma Tyrosine Tyrosine Kinase Inhibitors Young Adult
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