Granulosa Cells-Related MicroRNAs in Ovarian Diseases: Mechanism, Facts and Perspectives
MicroRNAs (miRNAs) are a class of short single-stranded, noncoding RNAs that affect the translation of mRNAs by imperfectly binding to homologous 3’UTRs. Research on miRNAs in ovarian diseases is constantly expanding because miRNAs are powerful regulators of gene expression and cellular processes an...
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| Veröffentlicht in: | Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2024-12, Vol.31 (12), p.3635-3650 |
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| creator | Xiao, Shengmin Du, Juan Yuan, Guanghui Luo, Xiaohong Song, Linjiang |
| description | MicroRNAs (miRNAs) are a class of short single-stranded, noncoding RNAs that affect the translation of mRNAs by imperfectly binding to homologous 3’UTRs. Research on miRNAs in ovarian diseases is constantly expanding because miRNAs are powerful regulators of gene expression and cellular processes and are promising biomarkers. miRNA mimics, miRNA inhibitors and molecules targeting miRNAs (antimiRs) have shown promise as novel therapeutic agents in preclinical development. Granulosa cells (GCs) are supporting cells for developing oocytes in the ovary. GCs regulate female reproductive health by producing sex hormones and LH receptors. Increasing research has reported the relevance of miRNAs in GC pathophysiology. With in-depth studies of disease mechanisms, there are an increasing number of studies on the biomolecular pathways of miRNAs in gynecology and endocrinology. In the present review, we summarize the different functions of GC-related microRNAs in various ovarian disorders, such as polycystic ovary syndrome, premature ovarian insufficiency, premature ovarian failure and ovarian granulosa cell tumors. |
| doi_str_mv | 10.1007/s43032-024-01523-w |
| format | Article |
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Research on miRNAs in ovarian diseases is constantly expanding because miRNAs are powerful regulators of gene expression and cellular processes and are promising biomarkers. miRNA mimics, miRNA inhibitors and molecules targeting miRNAs (antimiRs) have shown promise as novel therapeutic agents in preclinical development. Granulosa cells (GCs) are supporting cells for developing oocytes in the ovary. GCs regulate female reproductive health by producing sex hormones and LH receptors. Increasing research has reported the relevance of miRNAs in GC pathophysiology. With in-depth studies of disease mechanisms, there are an increasing number of studies on the biomolecular pathways of miRNAs in gynecology and endocrinology. 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| subjects | Animals Embryology Female Granulosa Cells - metabolism Humans Medicine Medicine & Public Health MicroRNAs - genetics MicroRNAs - metabolism Obstetrics/Perinatology/Midwifery Ovarian Diseases - genetics Ovarian Diseases - metabolism Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Polycystic Ovary Syndrome - genetics Polycystic Ovary Syndrome - metabolism Reproductive Biology: Review Reproductive Medicine |
| title | Granulosa Cells-Related MicroRNAs in Ovarian Diseases: Mechanism, Facts and Perspectives |
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