cGAS suppresses hepatocellular carcinoma independent of its cGAMP synthase activity

Cyclic GMP–AMP synthase (cGAS) is a key innate immune sensor that recognizes cytosolic DNA to induce immune responses against invading pathogens. The role of cGAS is conventionally recognized as a nucleotidyltransferase to catalyze the synthesis of cGAMP upon recognition of cytosolic DNA, which lead...

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Veröffentlicht in:	Cell death and differentiation 2024-06, Vol.31 (6), p.722-737
Hauptverfasser:	Ma, Dapeng, Yang, Min, Sun, Caiyu, Cui, Xiuling, Xiong, Gaozhong, Wang, Qiushi, Jing, Weiqiang, Chen, Haiqiang, Lv, Xiaoting, Liu, Shili, Li, Tao, Zhao, Yunxue, Han, Lihui
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 13/1 13/109 13/51 13/89 13/95 14/5 14/63 59 64 64/60 692/308/1426 692/699/67/1244 AKT protein Animal models Animals Apoptosis Biochemistry Biomedical and Life Sciences Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Biology Cell Cycle Analysis Cell Line, Tumor Hepatocellular carcinoma Hepatocytes Humans Immune response Kinases Life Sciences Liver cancer Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Malignancy Mechanistic Target of Rapamycin Complex 1 - metabolism Mice Mice, Nude Nucleotides, Cyclic - metabolism Nucleotidyltransferases - metabolism Pathogens Phosphatidylinositol 3-Kinases - metabolism Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism Protein-tyrosine-phosphatase Proto-Oncogene Proteins c-akt - metabolism SHP-1 protein Signal Transduction Stem Cells Tumor suppressor genes
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