Engineering Wet‐Resistant and Osteogenic Nanocomposite Adhesive to Control Bleeding and Infection after Median Sternotomy
Median sternotomy surgery stands as one of the prevailing strategies in cardiac surgery. In this study, the cutting‐edge bone adhesive is designed, inspired by the impressive adhesive properties found in mussels and sandcastle worms. This work has created an osteogenic nanocomposite coacervate adhes...
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| Veröffentlicht in: | Advanced healthcare materials 2024-07, Vol.13 (19), p.e2304349-n/a |
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| creator | Shokri, Mahshid Kharaziha, Mahshid Ahmadi Tafti, Hossein Dalili, Faezeh Mehdinavaz Aghdam, Rouhollah Baghaban Eslaminejad, Mohamadreza |
| description | Median sternotomy surgery stands as one of the prevailing strategies in cardiac surgery. In this study, the cutting‐edge bone adhesive is designed, inspired by the impressive adhesive properties found in mussels and sandcastle worms. This work has created an osteogenic nanocomposite coacervate adhesive by integrating a cellulose‐polyphosphodopamide interpenetrating network, quaternized chitosan, and zinc, gallium‐doped hydroxyapatite nanoparticles. This adhesive is characterized by robust catechol–metal coordination which effectively adheres to both hard and soft tissues with a maximum adhesive strength of 900 ± 38 kPa on the sheep sternum bone, surpassing that of commercial bone adhesives. The release of zinc and gallium cations from nanocomposite adhesives and quaternized chitosan matrix imparts remarkable antibacterial properties and promotes rapid blood coagulation, in vitro and ex vivo. It is also proved that this nanocomposite adhesive exhibits significant in vitro bioactivity, stable degradability, biocompatibility, and osteogenic ability. Furthermore, the capacity of nanocomposite coacervate to adhere to bone tissue and support osteogenesis contributes to the successful healing of a sternum bone defect in a rabbit model in vivo. In summary, these nanocomposite coacervate adhesives with promising characteristics are expected to provide solutions to clinical issues faced during median sternotomy surgery.
A nanocomposite coacervate adhesive based on a cellulose‐polyphosphodopamide interpenetrating network, quaternized chitosan, and zinc, gallium‐doped hydroxyapatite nanoparticles is developed. This hydrogel shows significant adhesive, antibacterial, hemostatic, and osteogenic properties for median sternotomy surgery. |
| doi_str_mv | 10.1002/adhm.202304349 |
| format | Article |
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A nanocomposite coacervate adhesive based on a cellulose‐polyphosphodopamide interpenetrating network, quaternized chitosan, and zinc, gallium‐doped hydroxyapatite nanoparticles is developed. This hydrogel shows significant adhesive, antibacterial, hemostatic, and osteogenic properties for median sternotomy surgery.</description><identifier>ISSN: 2192-2640</identifier><identifier>ISSN: 2192-2659</identifier><identifier>EISSN: 2192-2659</identifier><identifier>DOI: 10.1002/adhm.202304349</identifier><identifier>PMID: 38593272</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Adhesive strength ; Adhesives ; Biocompatibility ; Biological activity ; Biomedical materials ; Blood coagulation ; Bone healing ; Bone matrix ; Bone surgery ; bone tissue engineering ; Catechol ; Cations ; Cell adhesion ; Cellulose ; Chitosan ; coacervate complex ; Cutting resistance ; Degradability ; Gallium ; hemostatic ; Hydroxyapatite ; infection ; Interpenetrating networks ; Mussels ; nanocomposite bioadhesive ; Nanocomposites ; Nanoparticles ; Osteogenesis ; Soft tissues ; sternotomy ; Sternum ; Surgery ; Zinc</subject><ispartof>Advanced healthcare materials, 2024-07, Vol.13 (19), p.e2304349-n/a</ispartof><rights>2024 Wiley‐VCH GmbH</rights><rights>This article is protected by copyright. All rights reserved.</rights><rights>2024 Wiley‐VCH GmbH.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3289-c6ec636de5231568a8958af8c49c30ceeffb40518b904699bd130e1c719cb0993</cites><orcidid>0000-0002-8803-105X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadhm.202304349$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadhm.202304349$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38593272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shokri, Mahshid</creatorcontrib><creatorcontrib>Kharaziha, Mahshid</creatorcontrib><creatorcontrib>Ahmadi Tafti, Hossein</creatorcontrib><creatorcontrib>Dalili, Faezeh</creatorcontrib><creatorcontrib>Mehdinavaz Aghdam, Rouhollah</creatorcontrib><creatorcontrib>Baghaban Eslaminejad, Mohamadreza</creatorcontrib><title>Engineering Wet‐Resistant and Osteogenic Nanocomposite Adhesive to Control Bleeding and Infection after Median Sternotomy</title><title>Advanced healthcare materials</title><addtitle>Adv Healthc Mater</addtitle><description>Median sternotomy surgery stands as one of the prevailing strategies in cardiac surgery. In this study, the cutting‐edge bone adhesive is designed, inspired by the impressive adhesive properties found in mussels and sandcastle worms. This work has created an osteogenic nanocomposite coacervate adhesive by integrating a cellulose‐polyphosphodopamide interpenetrating network, quaternized chitosan, and zinc, gallium‐doped hydroxyapatite nanoparticles. This adhesive is characterized by robust catechol–metal coordination which effectively adheres to both hard and soft tissues with a maximum adhesive strength of 900 ± 38 kPa on the sheep sternum bone, surpassing that of commercial bone adhesives. The release of zinc and gallium cations from nanocomposite adhesives and quaternized chitosan matrix imparts remarkable antibacterial properties and promotes rapid blood coagulation, in vitro and ex vivo. It is also proved that this nanocomposite adhesive exhibits significant in vitro bioactivity, stable degradability, biocompatibility, and osteogenic ability. Furthermore, the capacity of nanocomposite coacervate to adhere to bone tissue and support osteogenesis contributes to the successful healing of a sternum bone defect in a rabbit model in vivo. In summary, these nanocomposite coacervate adhesives with promising characteristics are expected to provide solutions to clinical issues faced during median sternotomy surgery.
A nanocomposite coacervate adhesive based on a cellulose‐polyphosphodopamide interpenetrating network, quaternized chitosan, and zinc, gallium‐doped hydroxyapatite nanoparticles is developed. This hydrogel shows significant adhesive, antibacterial, hemostatic, and osteogenic properties for median sternotomy surgery.</description><subject>Adhesive strength</subject><subject>Adhesives</subject><subject>Biocompatibility</subject><subject>Biological activity</subject><subject>Biomedical materials</subject><subject>Blood coagulation</subject><subject>Bone healing</subject><subject>Bone matrix</subject><subject>Bone surgery</subject><subject>bone tissue engineering</subject><subject>Catechol</subject><subject>Cations</subject><subject>Cell adhesion</subject><subject>Cellulose</subject><subject>Chitosan</subject><subject>coacervate complex</subject><subject>Cutting resistance</subject><subject>Degradability</subject><subject>Gallium</subject><subject>hemostatic</subject><subject>Hydroxyapatite</subject><subject>infection</subject><subject>Interpenetrating networks</subject><subject>Mussels</subject><subject>nanocomposite bioadhesive</subject><subject>Nanocomposites</subject><subject>Nanoparticles</subject><subject>Osteogenesis</subject><subject>Soft tissues</subject><subject>sternotomy</subject><subject>Sternum</subject><subject>Surgery</subject><subject>Zinc</subject><issn>2192-2640</issn><issn>2192-2659</issn><issn>2192-2659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkU1rGzEQhkVpaUKaa45F0EsvdvWx0kpHx02TQNJAP-hx0WpnHYVdyZHkFpNLfkJ-Y35JZJy40EvnMgPzzMPAi9ARJVNKCPtkuutxygjjpOKVfoX2GdVswqTQr3dzRfbQYUo3pJQUVCr6Fu1xJTRnNdtHdyd-4TxAdH6Bf0F-vH_4BsmlbHzGxnf4KmUIC_DO4q_GBxvGZUguA5511wX8DTgHPA8-xzDg4wGg25g2l-e-B5td8Nj0GSK-LCvj8fcy-5DDuH6H3vRmSHD43A_Qzy8nP-Znk4ur0_P57GJiOVN6YiVYyWUHgnEqpDJKC2V6ZSttObEAfd9WRFDValJJrduOcgLU1lTblmjND9DHrXcZw-0KUm5GlywMg_EQVqnhhAvBdc3rgn74B70Jq-jLd4VSlaxpsRZquqVsDClF6JtldKOJ64aSZpNMs0mm2SVTDt4_a1ftCN0Of8mhAHoL_HEDrP-ja2afzy7_yp8A8Aib3A</recordid><startdate>20240701</startdate><enddate>20240701</enddate><creator>Shokri, Mahshid</creator><creator>Kharaziha, Mahshid</creator><creator>Ahmadi Tafti, Hossein</creator><creator>Dalili, Faezeh</creator><creator>Mehdinavaz Aghdam, Rouhollah</creator><creator>Baghaban Eslaminejad, Mohamadreza</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T5</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7TO</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8803-105X</orcidid></search><sort><creationdate>20240701</creationdate><title>Engineering Wet‐Resistant and Osteogenic Nanocomposite Adhesive to Control Bleeding and Infection after Median Sternotomy</title><author>Shokri, Mahshid ; 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In this study, the cutting‐edge bone adhesive is designed, inspired by the impressive adhesive properties found in mussels and sandcastle worms. This work has created an osteogenic nanocomposite coacervate adhesive by integrating a cellulose‐polyphosphodopamide interpenetrating network, quaternized chitosan, and zinc, gallium‐doped hydroxyapatite nanoparticles. This adhesive is characterized by robust catechol–metal coordination which effectively adheres to both hard and soft tissues with a maximum adhesive strength of 900 ± 38 kPa on the sheep sternum bone, surpassing that of commercial bone adhesives. The release of zinc and gallium cations from nanocomposite adhesives and quaternized chitosan matrix imparts remarkable antibacterial properties and promotes rapid blood coagulation, in vitro and ex vivo. It is also proved that this nanocomposite adhesive exhibits significant in vitro bioactivity, stable degradability, biocompatibility, and osteogenic ability. Furthermore, the capacity of nanocomposite coacervate to adhere to bone tissue and support osteogenesis contributes to the successful healing of a sternum bone defect in a rabbit model in vivo. In summary, these nanocomposite coacervate adhesives with promising characteristics are expected to provide solutions to clinical issues faced during median sternotomy surgery.
A nanocomposite coacervate adhesive based on a cellulose‐polyphosphodopamide interpenetrating network, quaternized chitosan, and zinc, gallium‐doped hydroxyapatite nanoparticles is developed. This hydrogel shows significant adhesive, antibacterial, hemostatic, and osteogenic properties for median sternotomy surgery.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38593272</pmid><doi>10.1002/adhm.202304349</doi><tpages>20</tpages><orcidid>https://orcid.org/0000-0002-8803-105X</orcidid></addata></record> |
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| subjects | Adhesive strength Adhesives Biocompatibility Biological activity Biomedical materials Blood coagulation Bone healing Bone matrix Bone surgery bone tissue engineering Catechol Cations Cell adhesion Cellulose Chitosan coacervate complex Cutting resistance Degradability Gallium hemostatic Hydroxyapatite infection Interpenetrating networks Mussels nanocomposite bioadhesive Nanocomposites Nanoparticles Osteogenesis Soft tissues sternotomy Sternum Surgery Zinc |
| title | Engineering Wet‐Resistant and Osteogenic Nanocomposite Adhesive to Control Bleeding and Infection after Median Sternotomy |
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