Genetic interactions reveal distinct biological and therapeutic implications in breast cancer

Co-occurrence and mutual exclusivity of genomic alterations may reflect the existence of genetic interactions, potentially shaping distinct biological phenotypes and impacting therapeutic response in breast cancer. However, our understanding of them remains limited. Herein, we investigate a large-sc...

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Veröffentlicht in:	Cancer cell 2024-04, Vol.42 (4), p.701-719.e12
Hauptverfasser:	Lin, Cai-Jin, Jin, Xi, Ma, Ding, Chen, Chao, Ou-Yang, Yang, Pei, Yu-Chen, Zhou, Chao-Zheng, Qu, Fei-Lin, Wang, Yun-Jin, Liu, Cheng-Lin, Fan, Lei, Hu, Xin, Shao, Zhi-Ming, Jiang, Yi-Zhou
Format:	Artikel
Sprache:	eng
Schlagworte:	breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - pathology clinical sequencing co-occurrence Female Genomics Humans multi-omics Mutation mutual exclusivity Phenotype precision treatment Treatment Outcome
Online-Zugang:	Volltext
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