BLM helicase unwinds lagging strand substrates to assemble the ALT telomere damage response

The Bloom syndrome (BLM) helicase is critical for alternative lengthening of telomeres (ALT), a homology-directed repair (HDR)-mediated telomere maintenance mechanism that is prevalent in cancers of mesenchymal origin. The DNA substrates that BLM engages to direct telomere recombination during ALT r...

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Veröffentlicht in:	Molecular cell 2024-05, Vol.84 (9), p.1684-1698.e9
Hauptverfasser:	Jiang, Haoyang, Zhang, Tianpeng, Kaur, Hardeep, Shi, Tao, Krishnan, Aravind, Kwon, Youngho, Sung, Patrick, Greenberg, Roger A.
Format:	Artikel
Sprache:	eng
Schlagworte:	alternative lengthening of telomeres ATRX BLM helicase Bloom Syndrome - enzymology Bloom Syndrome - genetics Bloom Syndrome - metabolism Bloom Syndrome - pathology Cell Line, Tumor DNA Damage DNA damage response DNA Helicases - genetics DNA Helicases - metabolism DNA Replication DNA, Single-Stranded - genetics DNA, Single-Stranded - metabolism Humans RecQ Helicases - genetics RecQ Helicases - metabolism telomere Telomere - genetics Telomere - metabolism Telomere Homeostasis X-linked Nuclear Protein - genetics X-linked Nuclear Protein - metabolism
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