Estimation of persistent sodium‐current density in rat hippocampal mossy fibre boutons: Correction of space‐clamp errors

We used whole‐cell patch clamp to estimate the stationary voltage dependence of persistent sodium‐current density (iNaP) in rat hippocampal mossy fibre boutons. Cox's method for correcting space‐clamp errors was extended to the case of an isopotential compartment with attached neurites. The met...

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Veröffentlicht in:	The Journal of physiology 2024-04, Vol.602 (8), p.1703-1732
Hauptverfasser:	Murphy, Ricardo, Alle, Henrik, Geiger, Jörg R. P., Storm, Johan F.
Format:	Artikel
Sprache:	eng
Schlagworte:	axon Axons compartmental modelling dentate granule cell Excitatory postsynaptic potentials Granule cells Hippocampus Hodgkin-Huxley model Mossy fibers mossy fibre patch clamp persistent sodium current Potassium chloride Presynapse Sodium Sodium channels (voltage-gated) Sodium conductance space clamp voltage ramp
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