Novel multifunctional tacrine–donepezil hybrids against Alzheimer's disease: Design synthesis and bioactivity studies

A series of tacrine–donepezil hybrids were synthesized as potential multifunctional anti‐Alzheimer's disease (AD) compounds. For this purpose, tacrine and the benzylpiperidine moiety of donepezil were fused with a hydrazone group to achieve a small library of tacrine–donepezil hybrids. In agree...

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Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 2024-07, Vol.357 (7), p.e2300575-n/a
Hauptverfasser:	Bayraktar, Gülşah, Bartolini, Manuela, Bolognesi, Maria Laura, Erdoğan, Mumin Alper, Armağan, Güliz, Bayır, Ece, Şendemir, Aylin, Bagetta, Donatella, Alcaro, Stefano, Alptüzün, Vildan
Format:	Artikel
Sprache:	eng
Schlagworte:	AChE inhibition Alzheimer's disease BBB permeability BChE inhibition neuroprotection tacrine–donepezil hybrid
Online-Zugang:	Volltext
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