A promising future of metal‐N‐heterocyclic carbene complexes in medicinal chemistry: The emerging bioorganometallic antitumor agents

Metal complexes based on N‐heterocyclic carbene (NHC) ligands have emerged as promising broad‐spectrum antitumor agents in bioorganometallic medicinal chemistry. In recent decades, studies on cytotoxic metal–NHC complexes have yielded numerous compounds exhibiting superior cytotoxicity compared to c...

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Veröffentlicht in:	Medicinal research reviews 2024-09, Vol.44 (5), p.2194-2235
Hauptverfasser:	Zhao, Qian, Han, Bo, Peng, Cheng, Zhang, Nan, Huang, Wei, He, Gu, Li, Jun‐Long
Format:	Artikel
Sprache:	eng
Schlagworte:	antitumor Apoptosis Cytotoxicity Endoplasmic reticulum mechanism metal‐N‐heterocyclic carbene complexes Mitochondria Pharmaceutical sciences Platinum structure‐activity relationship
Online-Zugang:	Volltext
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