Characteristics of spatial protein expression in the mouse cochlear sensory epithelia: Implications for age-related hearing loss

•Thousands of proteins in the cochlear sensory epithelia were detected by microscale proteomics.•Hundreds of spatially differentially expressed proteins were detected in the cochlear sensory epithelia.•Protein levels were stable in the upper half of the cochlear sensory epithelia during early aging....

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Veröffentlicht in:	Hearing research 2024-05, Vol.446, p.109006-109006, Article 109006
Hauptverfasser:	Lao, Huilin, Zhu, Yafeng, Yang, Mei, Wang, Lingshuo, Tang, Jie, Xiong, Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Age-related hearing loss Aging - metabolism Aging - pathology Animals Cochlea Cochlea - metabolism Cochlea - pathology Disease Models, Animal Epithelium - metabolism Gradient Hair Cells, Auditory - metabolism Hair Cells, Auditory - pathology Hearing Male Mice Mice, Inbred C57BL Presbycusis - genetics Presbycusis - metabolism Presbycusis - pathology Presbycusis - physiopathology Proteomics Sensory epithelia Tonotopy
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