Intrascleral intraocular lens fixation with ab interno trabeculotomy in patients with exfoliation glaucoma with lens subluxation
Purpose To evaluate the surgical outcomes of intrascleral intraocular lens (IOL) fixation using ab interno trabeculotomy (LOT) in patients with exfoliation glaucoma with lens subluxation. Study design Retrospective case series. Methods Twenty eyes of 18 patients with exfoliation glaucoma and lens or...
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| Veröffentlicht in: | Japanese journal of ophthalmology 2024-05, Vol.68 (3), p.200-205 |
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| creator | Arimatsu, Mao Akagi, Tadamichi Suetake, Aki Sakaue, Yuta Iikawa, Ryu Igarashi, Ryoko Togano, Tetsuya Ando, Takumi Yoshida, Hiromitsu Terashima, Hiroko Fukuchi, Takeo |
| description | Purpose
To evaluate the surgical outcomes of intrascleral intraocular lens (IOL) fixation using ab interno trabeculotomy (LOT) in patients with exfoliation glaucoma with lens subluxation.
Study design
Retrospective case series.
Methods
Twenty eyes of 18 patients with exfoliation glaucoma and lens or IOL subluxations were included. Three success criteria were based on postoperative intraocular pressure (IOP) (A, ≤15 mmHg; B, ≤18 mmHg; C, ≤21 mmHg). The IOP, number of glaucoma medications, and visual acuity were compared before and after surgery. Success probability was analyzed using Kaplan–Meier survival curves. Cox proportional hazards’ regression models were used to examine prognostic factors for surgical failure.
Results
The mean follow-up period was 23.4 ± 7.8 months. The mean IOP significantly decreased from 23.2 ± 6.8 mmHg preoperatively to 14.0 ± 4.4 mmHg at 1 year postoperative (
P |
| doi_str_mv | 10.1007/s10384-024-01059-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3034777861</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3053546603</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-8afb007f61d4dee128a231f3961e4c2c7c56514e6efa6797763ae253901adf603</originalsourceid><addsrcrecordid>eNp9kU1PwyAYx4nR6Jx-AQ-miRcvVV4KdEez-JYs8aJnQtnD7ELLhDa6mx9dtk5NPHggBJ4fP-D5I3RG8BXBWF5HgllZ5JimQTCf5GQPjYggLKe0EPtohDElOSecH6HjGJcY44IyeoiOWMlLKUs5Qp-PbRd0NA6Cdlm9WXjTOx0yB23MbP2hu9q32XvdvWa62hAQWp8lroIE-s4367SbrRIHbRcHEj6sd_VwdOF0b3yjh8pWG_vK9YP5BB1Y7SKc7uYxerm7fZ4-5LOn-8fpzSw3jIouL7Wt0p-tIPNiDkBoqSkjlk0EgcJQIw0XnBQgwGohJ1IKpoFyNsFEz63AbIwuB-8q-LceYqeaOhpwTrfg-6gYZoVMPUntG6OLP-jS96FNr0sUZ7wQyZcoOlAm-BgDWLUKdaPDWhGsNvmoIR-V8lHbfNRGfb5T91UD858j34EkgA1ATKV2AeH37n-0X0sBnbc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3053546603</pqid></control><display><type>article</type><title>Intrascleral intraocular lens fixation with ab interno trabeculotomy in patients with exfoliation glaucoma with lens subluxation</title><source>SpringerLink Journals</source><creator>Arimatsu, Mao ; Akagi, Tadamichi ; Suetake, Aki ; Sakaue, Yuta ; Iikawa, Ryu ; Igarashi, Ryoko ; Togano, Tetsuya ; Ando, Takumi ; Yoshida, Hiromitsu ; Terashima, Hiroko ; Fukuchi, Takeo</creator><creatorcontrib>Arimatsu, Mao ; Akagi, Tadamichi ; Suetake, Aki ; Sakaue, Yuta ; Iikawa, Ryu ; Igarashi, Ryoko ; Togano, Tetsuya ; Ando, Takumi ; Yoshida, Hiromitsu ; Terashima, Hiroko ; Fukuchi, Takeo</creatorcontrib><description>Purpose
To evaluate the surgical outcomes of intrascleral intraocular lens (IOL) fixation using ab interno trabeculotomy (LOT) in patients with exfoliation glaucoma with lens subluxation.
Study design
Retrospective case series.
Methods
Twenty eyes of 18 patients with exfoliation glaucoma and lens or IOL subluxations were included. Three success criteria were based on postoperative intraocular pressure (IOP) (A, ≤15 mmHg; B, ≤18 mmHg; C, ≤21 mmHg). The IOP, number of glaucoma medications, and visual acuity were compared before and after surgery. Success probability was analyzed using Kaplan–Meier survival curves. Cox proportional hazards’ regression models were used to examine prognostic factors for surgical failure.
Results
The mean follow-up period was 23.4 ± 7.8 months. The mean IOP significantly decreased from 23.2 ± 6.8 mmHg preoperatively to 14.0 ± 4.4 mmHg at 1 year postoperative (
P
<0.001). Postoperative hyphema and vitreous hemorrhage were observed in seven and 15 eyes, respectively, and washout in the anterior chamber or vitreous cavity was performed in four eyes. Postoperative IOP spikes and hypotony were observed in four eyes each. Glaucoma reoperation was performed in two eyes. The success rates at 12 months were 65%, 85%, and 90% using criteria A, B, and C, respectively. The IOP at 1 month after surgery was a significant prognostic factor for surgical failure according to criterion A (hazard ratio: 1.08;
P
=0.034).
Conclusion
Intrascleral IOL fixation combined with microhook LOT is a promising option in cases of exfoliation glaucoma with subluxated lens/IOL; however, the high rate of postoperative hyphema and vitreous hemorrhage should be noted.</description><identifier>ISSN: 0021-5155</identifier><identifier>EISSN: 1613-2246</identifier><identifier>DOI: 10.1007/s10384-024-01059-1</identifier><identifier>PMID: 38587787</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Acuity ; Anterior chamber ; Clinical Investigation ; Criteria ; Exfoliation ; Eye ; Fixation ; Glaucoma ; Hemorrhage ; Intraocular lenses ; Intraocular pressure ; Medical prognosis ; Medicine ; Medicine & Public Health ; Ophthalmology ; Regression analysis ; Regression models ; Statistical analysis ; Surgery ; Surgical outcomes ; Visual acuity</subject><ispartof>Japanese journal of ophthalmology, 2024-05, Vol.68 (3), p.200-205</ispartof><rights>Japanese Ophthalmological Society 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. Japanese Ophthalmological Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-8afb007f61d4dee128a231f3961e4c2c7c56514e6efa6797763ae253901adf603</cites><orcidid>0000-0003-1461-8808</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10384-024-01059-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10384-024-01059-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38587787$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arimatsu, Mao</creatorcontrib><creatorcontrib>Akagi, Tadamichi</creatorcontrib><creatorcontrib>Suetake, Aki</creatorcontrib><creatorcontrib>Sakaue, Yuta</creatorcontrib><creatorcontrib>Iikawa, Ryu</creatorcontrib><creatorcontrib>Igarashi, Ryoko</creatorcontrib><creatorcontrib>Togano, Tetsuya</creatorcontrib><creatorcontrib>Ando, Takumi</creatorcontrib><creatorcontrib>Yoshida, Hiromitsu</creatorcontrib><creatorcontrib>Terashima, Hiroko</creatorcontrib><creatorcontrib>Fukuchi, Takeo</creatorcontrib><title>Intrascleral intraocular lens fixation with ab interno trabeculotomy in patients with exfoliation glaucoma with lens subluxation</title><title>Japanese journal of ophthalmology</title><addtitle>Jpn J Ophthalmol</addtitle><addtitle>Jpn J Ophthalmol</addtitle><description>Purpose
To evaluate the surgical outcomes of intrascleral intraocular lens (IOL) fixation using ab interno trabeculotomy (LOT) in patients with exfoliation glaucoma with lens subluxation.
Study design
Retrospective case series.
Methods
Twenty eyes of 18 patients with exfoliation glaucoma and lens or IOL subluxations were included. Three success criteria were based on postoperative intraocular pressure (IOP) (A, ≤15 mmHg; B, ≤18 mmHg; C, ≤21 mmHg). The IOP, number of glaucoma medications, and visual acuity were compared before and after surgery. Success probability was analyzed using Kaplan–Meier survival curves. Cox proportional hazards’ regression models were used to examine prognostic factors for surgical failure.
Results
The mean follow-up period was 23.4 ± 7.8 months. The mean IOP significantly decreased from 23.2 ± 6.8 mmHg preoperatively to 14.0 ± 4.4 mmHg at 1 year postoperative (
P
<0.001). Postoperative hyphema and vitreous hemorrhage were observed in seven and 15 eyes, respectively, and washout in the anterior chamber or vitreous cavity was performed in four eyes. Postoperative IOP spikes and hypotony were observed in four eyes each. Glaucoma reoperation was performed in two eyes. The success rates at 12 months were 65%, 85%, and 90% using criteria A, B, and C, respectively. The IOP at 1 month after surgery was a significant prognostic factor for surgical failure according to criterion A (hazard ratio: 1.08;
P
=0.034).
Conclusion
Intrascleral IOL fixation combined with microhook LOT is a promising option in cases of exfoliation glaucoma with subluxated lens/IOL; however, the high rate of postoperative hyphema and vitreous hemorrhage should be noted.</description><subject>Acuity</subject><subject>Anterior chamber</subject><subject>Clinical Investigation</subject><subject>Criteria</subject><subject>Exfoliation</subject><subject>Eye</subject><subject>Fixation</subject><subject>Glaucoma</subject><subject>Hemorrhage</subject><subject>Intraocular lenses</subject><subject>Intraocular pressure</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Statistical analysis</subject><subject>Surgery</subject><subject>Surgical outcomes</subject><subject>Visual acuity</subject><issn>0021-5155</issn><issn>1613-2246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kU1PwyAYx4nR6Jx-AQ-miRcvVV4KdEez-JYs8aJnQtnD7ELLhDa6mx9dtk5NPHggBJ4fP-D5I3RG8BXBWF5HgllZ5JimQTCf5GQPjYggLKe0EPtohDElOSecH6HjGJcY44IyeoiOWMlLKUs5Qp-PbRd0NA6Cdlm9WXjTOx0yB23MbP2hu9q32XvdvWa62hAQWp8lroIE-s4367SbrRIHbRcHEj6sd_VwdOF0b3yjh8pWG_vK9YP5BB1Y7SKc7uYxerm7fZ4-5LOn-8fpzSw3jIouL7Wt0p-tIPNiDkBoqSkjlk0EgcJQIw0XnBQgwGohJ1IKpoFyNsFEz63AbIwuB-8q-LceYqeaOhpwTrfg-6gYZoVMPUntG6OLP-jS96FNr0sUZ7wQyZcoOlAm-BgDWLUKdaPDWhGsNvmoIR-V8lHbfNRGfb5T91UD858j34EkgA1ATKV2AeH37n-0X0sBnbc</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Arimatsu, Mao</creator><creator>Akagi, Tadamichi</creator><creator>Suetake, Aki</creator><creator>Sakaue, Yuta</creator><creator>Iikawa, Ryu</creator><creator>Igarashi, Ryoko</creator><creator>Togano, Tetsuya</creator><creator>Ando, Takumi</creator><creator>Yoshida, Hiromitsu</creator><creator>Terashima, Hiroko</creator><creator>Fukuchi, Takeo</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1461-8808</orcidid></search><sort><creationdate>20240501</creationdate><title>Intrascleral intraocular lens fixation with ab interno trabeculotomy in patients with exfoliation glaucoma with lens subluxation</title><author>Arimatsu, Mao ; Akagi, Tadamichi ; Suetake, Aki ; Sakaue, Yuta ; Iikawa, Ryu ; Igarashi, Ryoko ; Togano, Tetsuya ; Ando, Takumi ; Yoshida, Hiromitsu ; Terashima, Hiroko ; Fukuchi, Takeo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-8afb007f61d4dee128a231f3961e4c2c7c56514e6efa6797763ae253901adf603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acuity</topic><topic>Anterior chamber</topic><topic>Clinical Investigation</topic><topic>Criteria</topic><topic>Exfoliation</topic><topic>Eye</topic><topic>Fixation</topic><topic>Glaucoma</topic><topic>Hemorrhage</topic><topic>Intraocular lenses</topic><topic>Intraocular pressure</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Regression analysis</topic><topic>Regression models</topic><topic>Statistical analysis</topic><topic>Surgery</topic><topic>Surgical outcomes</topic><topic>Visual acuity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arimatsu, Mao</creatorcontrib><creatorcontrib>Akagi, Tadamichi</creatorcontrib><creatorcontrib>Suetake, Aki</creatorcontrib><creatorcontrib>Sakaue, Yuta</creatorcontrib><creatorcontrib>Iikawa, Ryu</creatorcontrib><creatorcontrib>Igarashi, Ryoko</creatorcontrib><creatorcontrib>Togano, Tetsuya</creatorcontrib><creatorcontrib>Ando, Takumi</creatorcontrib><creatorcontrib>Yoshida, Hiromitsu</creatorcontrib><creatorcontrib>Terashima, Hiroko</creatorcontrib><creatorcontrib>Fukuchi, Takeo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arimatsu, Mao</au><au>Akagi, Tadamichi</au><au>Suetake, Aki</au><au>Sakaue, Yuta</au><au>Iikawa, Ryu</au><au>Igarashi, Ryoko</au><au>Togano, Tetsuya</au><au>Ando, Takumi</au><au>Yoshida, Hiromitsu</au><au>Terashima, Hiroko</au><au>Fukuchi, Takeo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intrascleral intraocular lens fixation with ab interno trabeculotomy in patients with exfoliation glaucoma with lens subluxation</atitle><jtitle>Japanese journal of ophthalmology</jtitle><stitle>Jpn J Ophthalmol</stitle><addtitle>Jpn J Ophthalmol</addtitle><date>2024-05-01</date><risdate>2024</risdate><volume>68</volume><issue>3</issue><spage>200</spage><epage>205</epage><pages>200-205</pages><issn>0021-5155</issn><eissn>1613-2246</eissn><abstract>Purpose
To evaluate the surgical outcomes of intrascleral intraocular lens (IOL) fixation using ab interno trabeculotomy (LOT) in patients with exfoliation glaucoma with lens subluxation.
Study design
Retrospective case series.
Methods
Twenty eyes of 18 patients with exfoliation glaucoma and lens or IOL subluxations were included. Three success criteria were based on postoperative intraocular pressure (IOP) (A, ≤15 mmHg; B, ≤18 mmHg; C, ≤21 mmHg). The IOP, number of glaucoma medications, and visual acuity were compared before and after surgery. Success probability was analyzed using Kaplan–Meier survival curves. Cox proportional hazards’ regression models were used to examine prognostic factors for surgical failure.
Results
The mean follow-up period was 23.4 ± 7.8 months. The mean IOP significantly decreased from 23.2 ± 6.8 mmHg preoperatively to 14.0 ± 4.4 mmHg at 1 year postoperative (
P
<0.001). Postoperative hyphema and vitreous hemorrhage were observed in seven and 15 eyes, respectively, and washout in the anterior chamber or vitreous cavity was performed in four eyes. Postoperative IOP spikes and hypotony were observed in four eyes each. Glaucoma reoperation was performed in two eyes. The success rates at 12 months were 65%, 85%, and 90% using criteria A, B, and C, respectively. The IOP at 1 month after surgery was a significant prognostic factor for surgical failure according to criterion A (hazard ratio: 1.08;
P
=0.034).
Conclusion
Intrascleral IOL fixation combined with microhook LOT is a promising option in cases of exfoliation glaucoma with subluxated lens/IOL; however, the high rate of postoperative hyphema and vitreous hemorrhage should be noted.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>38587787</pmid><doi>10.1007/s10384-024-01059-1</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-1461-8808</orcidid></addata></record> |
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| subjects | Acuity Anterior chamber Clinical Investigation Criteria Exfoliation Eye Fixation Glaucoma Hemorrhage Intraocular lenses Intraocular pressure Medical prognosis Medicine Medicine & Public Health Ophthalmology Regression analysis Regression models Statistical analysis Surgery Surgical outcomes Visual acuity |
| title | Intrascleral intraocular lens fixation with ab interno trabeculotomy in patients with exfoliation glaucoma with lens subluxation |
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