Fetal hemodynamics and placental histopathology in Down syndrome

Objective To evaluate the association between Doppler patterns in fetuses with Down syndrome (DS) and their placental histopathologic findings. Methods A retrospective cross‐sectional study was performed by collecting data from medical records of singleton pregnancies between January 2014 and January 2022, whose fetuses had a confirmed diagnosis of DS either prenatally or postnatally. Placental histopathology, maternal characteristics, and prenatal ultrasound (biometric parameters and umbilical artery [UA] Doppler) were evaluated. Results Of 69 eligible pregnant women, 61 met the inclusion and exclusion criteria. In the sample, 15 fetuses had an estimated fetal weight