Armed with IL-2 based fusion protein improves CAR-T cell fitness and efficacy against solid tumors

Chimeric antigen receptor T (CAR-T) cell therapy is regarded as a potent immunotherapy and has made significant success in hematologic malignancies by eliciting antigen-specific immune responses. However, response rates of CAR-T cell therapy against solid tumors with immunosuppressive microenvironme...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2024-06, Vol.1870 (5), p.167159, Article 167159
Hauptverfasser:	Li, Sijin, Xia, Yifei, Hou, Rui, Wang, Xu, Zhao, Xuan, Guan, Zhangchun, Ma, Wen, Xu, Yutong, Zhang, Wei, Liu, Dan, Zheng, Junnian, Shi, Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive cellular immunotherapy Cell engineering Cytokine T cell Tumor microenvironment
Online-Zugang:	Volltext
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