Association between lactate dehydrogenase to albumin ratio and acute kidney injury in patients with sepsis: a retrospective cohort study
Background Serum lactate dehydrogenase to albumin ratio (LAR) is associated with poor outcomes in malignancy and pneumonia. However, there are few studies suggesting that LAR is associated with the occurrence of acute kidney injury (AKI) in patients with sepsis, which was investigated in this study....
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| Veröffentlicht in: | Clinical and experimental nephrology 2024-09, Vol.28 (9), p.882-893 |
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| creator | Xu, Weigan Huo, Jianyang Hu, Qiaohua Xu, Jingtao Chen, Guojun Mo, Jierong Zhou, Tianen Jiang, Jun |
| description | Background
Serum lactate dehydrogenase to albumin ratio (LAR) is associated with poor outcomes in malignancy and pneumonia. However, there are few studies suggesting that LAR is associated with the occurrence of acute kidney injury (AKI) in patients with sepsis, which was investigated in this study.
Methods
We conducted a retrospective cohort study based on the Medical Information Mart for Intensive Care (MIMIC)-IV database. The primary outcome was the occurrence of AKI within 2 days and 7 days. Multivariable logistic regression models were used to calculate odds ratios to validate the association between LAR and AKI, in-hospital mortality, RRT use, and recovery of renal function, respectively.
Results
A total of 4010 participants were included in this study. The median age of the participants was 63.5 years and the median LAR was 10.5. After adjusting for confounding variables, patients in the highest LAR quartile had a higher risk of AKI than those in the lowest LAR quartile within 2 days and 7 days, with odds ratios of 1.37 (95% confidence interval [CI]: 1.23–1.52) and 1.95 (95% CI: 1.72–2.22), respectively. The adjusted odds of AKI within 2 and 7 days were 1.16 (95% CI: 1.12–1.20) and 1.29 (95% CI: 1.24–1.35) for each 1 unit increase in LAR(log
2
), respectively.
Conclusion
This study demonstrated that elevated LAR was associated with poor prognosis in patients with sepsis. The risk of AKI and in-hospital mortality increased, the need for RRT increased, and the chance of recovery of renal function decreased with the increase of LAR. |
| doi_str_mv | 10.1007/s10157-024-02500-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3034772997</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3095839744</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-a160f6c5f13aa55338221ce5b521e9535726ade294d3e13f0999f04c9c0893b23</originalsourceid><addsrcrecordid>eNp9kU1v1DAQhi1ERUvhD3BAlrhwCfVHvI65VRVfUqVe4Gw5zqTrJWsHj9Mq_4CfjZctIHHowRpLfuYdjx5CXnH2jjOmL5AzrnTDRFuPYqxZn5Az3krdaG3M03qXrWi4VvyUPEfcMcY6o8wzcio71bXcqDPy8xIx-eBKSJH2UO4BIp2cL64AHWC7DjndQnQItCTqpn7Zh0jzgacuDtT5pYLfwxBhpSHulnwodK4AxIL0PpQtRZgx4HvqaIaSE87gS7gD6tM25UKxLMP6gpyMbkJ4-VDPybePH75efW6ubz59ubq8brwUm9I4vmHjxquRS-eUkrITgntQvRIcjJJKi40bQJh2kMDlyIwxI2u98XV32Qt5Tt4ec-ecfiyAxe4DepgmFyEtaCWTrdbCGF3RN_-hu7TkWH9XKaM6aXTbVkocKV83wwyjnXPYu7xazuzBkz16stWT_e3JrrXp9UP00u9h-NvyR0wF5BHA-hRvIf-b_UjsLyzkoD8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3095839744</pqid></control><display><type>article</type><title>Association between lactate dehydrogenase to albumin ratio and acute kidney injury in patients with sepsis: a retrospective cohort study</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Xu, Weigan ; Huo, Jianyang ; Hu, Qiaohua ; Xu, Jingtao ; Chen, Guojun ; Mo, Jierong ; Zhou, Tianen ; Jiang, Jun</creator><creatorcontrib>Xu, Weigan ; Huo, Jianyang ; Hu, Qiaohua ; Xu, Jingtao ; Chen, Guojun ; Mo, Jierong ; Zhou, Tianen ; Jiang, Jun</creatorcontrib><description>Background
Serum lactate dehydrogenase to albumin ratio (LAR) is associated with poor outcomes in malignancy and pneumonia. However, there are few studies suggesting that LAR is associated with the occurrence of acute kidney injury (AKI) in patients with sepsis, which was investigated in this study.
Methods
We conducted a retrospective cohort study based on the Medical Information Mart for Intensive Care (MIMIC)-IV database. The primary outcome was the occurrence of AKI within 2 days and 7 days. Multivariable logistic regression models were used to calculate odds ratios to validate the association between LAR and AKI, in-hospital mortality, RRT use, and recovery of renal function, respectively.
Results
A total of 4010 participants were included in this study. The median age of the participants was 63.5 years and the median LAR was 10.5. After adjusting for confounding variables, patients in the highest LAR quartile had a higher risk of AKI than those in the lowest LAR quartile within 2 days and 7 days, with odds ratios of 1.37 (95% confidence interval [CI]: 1.23–1.52) and 1.95 (95% CI: 1.72–2.22), respectively. The adjusted odds of AKI within 2 and 7 days were 1.16 (95% CI: 1.12–1.20) and 1.29 (95% CI: 1.24–1.35) for each 1 unit increase in LAR(log
2
), respectively.
Conclusion
This study demonstrated that elevated LAR was associated with poor prognosis in patients with sepsis. The risk of AKI and in-hospital mortality increased, the need for RRT increased, and the chance of recovery of renal function decreased with the increase of LAR.</description><identifier>ISSN: 1342-1751</identifier><identifier>ISSN: 1437-7799</identifier><identifier>EISSN: 1437-7799</identifier><identifier>DOI: 10.1007/s10157-024-02500-y</identifier><identifier>PMID: 38584195</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Acute Kidney Injury - blood ; Acute Kidney Injury - diagnosis ; Acute Kidney Injury - mortality ; Aged ; Albumin ; Biomarkers - blood ; Cohort analysis ; Dehydrogenases ; Female ; Hospital Mortality ; Humans ; Kidneys ; L-Lactate dehydrogenase ; L-Lactate Dehydrogenase - blood ; Lactic acid ; Male ; Malignancy ; Medicine ; Medicine & Public Health ; Middle Aged ; Mortality ; Nephrology ; Original Article ; Patients ; Regression analysis ; Renal function ; Renal Replacement Therapy ; Retrospective Studies ; Risk Factors ; Sepsis ; Sepsis - blood ; Sepsis - complications ; Serum Albumin, Human - analysis ; Urology</subject><ispartof>Clinical and experimental nephrology, 2024-09, Vol.28 (9), p.882-893</ispartof><rights>The Author(s), under exclusive licence to Japanese Society of Nephrology 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Japanese Society of Nephrology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-a160f6c5f13aa55338221ce5b521e9535726ade294d3e13f0999f04c9c0893b23</cites><orcidid>0000-0002-4440-7246</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10157-024-02500-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10157-024-02500-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38584195$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Weigan</creatorcontrib><creatorcontrib>Huo, Jianyang</creatorcontrib><creatorcontrib>Hu, Qiaohua</creatorcontrib><creatorcontrib>Xu, Jingtao</creatorcontrib><creatorcontrib>Chen, Guojun</creatorcontrib><creatorcontrib>Mo, Jierong</creatorcontrib><creatorcontrib>Zhou, Tianen</creatorcontrib><creatorcontrib>Jiang, Jun</creatorcontrib><title>Association between lactate dehydrogenase to albumin ratio and acute kidney injury in patients with sepsis: a retrospective cohort study</title><title>Clinical and experimental nephrology</title><addtitle>Clin Exp Nephrol</addtitle><addtitle>Clin Exp Nephrol</addtitle><description>Background
Serum lactate dehydrogenase to albumin ratio (LAR) is associated with poor outcomes in malignancy and pneumonia. However, there are few studies suggesting that LAR is associated with the occurrence of acute kidney injury (AKI) in patients with sepsis, which was investigated in this study.
Methods
We conducted a retrospective cohort study based on the Medical Information Mart for Intensive Care (MIMIC)-IV database. The primary outcome was the occurrence of AKI within 2 days and 7 days. Multivariable logistic regression models were used to calculate odds ratios to validate the association between LAR and AKI, in-hospital mortality, RRT use, and recovery of renal function, respectively.
Results
A total of 4010 participants were included in this study. The median age of the participants was 63.5 years and the median LAR was 10.5. After adjusting for confounding variables, patients in the highest LAR quartile had a higher risk of AKI than those in the lowest LAR quartile within 2 days and 7 days, with odds ratios of 1.37 (95% confidence interval [CI]: 1.23–1.52) and 1.95 (95% CI: 1.72–2.22), respectively. The adjusted odds of AKI within 2 and 7 days were 1.16 (95% CI: 1.12–1.20) and 1.29 (95% CI: 1.24–1.35) for each 1 unit increase in LAR(log
2
), respectively.
Conclusion
This study demonstrated that elevated LAR was associated with poor prognosis in patients with sepsis. The risk of AKI and in-hospital mortality increased, the need for RRT increased, and the chance of recovery of renal function decreased with the increase of LAR.</description><subject>Acute Kidney Injury - blood</subject><subject>Acute Kidney Injury - diagnosis</subject><subject>Acute Kidney Injury - mortality</subject><subject>Aged</subject><subject>Albumin</subject><subject>Biomarkers - blood</subject><subject>Cohort analysis</subject><subject>Dehydrogenases</subject><subject>Female</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Kidneys</subject><subject>L-Lactate dehydrogenase</subject><subject>L-Lactate Dehydrogenase - blood</subject><subject>Lactic acid</subject><subject>Male</subject><subject>Malignancy</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Nephrology</subject><subject>Original Article</subject><subject>Patients</subject><subject>Regression analysis</subject><subject>Renal function</subject><subject>Renal Replacement Therapy</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Sepsis</subject><subject>Sepsis - blood</subject><subject>Sepsis - complications</subject><subject>Serum Albumin, Human - analysis</subject><subject>Urology</subject><issn>1342-1751</issn><issn>1437-7799</issn><issn>1437-7799</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhi1ERUvhD3BAlrhwCfVHvI65VRVfUqVe4Gw5zqTrJWsHj9Mq_4CfjZctIHHowRpLfuYdjx5CXnH2jjOmL5AzrnTDRFuPYqxZn5Az3krdaG3M03qXrWi4VvyUPEfcMcY6o8wzcio71bXcqDPy8xIx-eBKSJH2UO4BIp2cL64AHWC7DjndQnQItCTqpn7Zh0jzgacuDtT5pYLfwxBhpSHulnwodK4AxIL0PpQtRZgx4HvqaIaSE87gS7gD6tM25UKxLMP6gpyMbkJ4-VDPybePH75efW6ubz59ubq8brwUm9I4vmHjxquRS-eUkrITgntQvRIcjJJKi40bQJh2kMDlyIwxI2u98XV32Qt5Tt4ec-ecfiyAxe4DepgmFyEtaCWTrdbCGF3RN_-hu7TkWH9XKaM6aXTbVkocKV83wwyjnXPYu7xazuzBkz16stWT_e3JrrXp9UP00u9h-NvyR0wF5BHA-hRvIf-b_UjsLyzkoD8</recordid><startdate>20240901</startdate><enddate>20240901</enddate><creator>Xu, Weigan</creator><creator>Huo, Jianyang</creator><creator>Hu, Qiaohua</creator><creator>Xu, Jingtao</creator><creator>Chen, Guojun</creator><creator>Mo, Jierong</creator><creator>Zhou, Tianen</creator><creator>Jiang, Jun</creator><general>Springer Nature Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4440-7246</orcidid></search><sort><creationdate>20240901</creationdate><title>Association between lactate dehydrogenase to albumin ratio and acute kidney injury in patients with sepsis: a retrospective cohort study</title><author>Xu, Weigan ; Huo, Jianyang ; Hu, Qiaohua ; Xu, Jingtao ; Chen, Guojun ; Mo, Jierong ; Zhou, Tianen ; Jiang, Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-a160f6c5f13aa55338221ce5b521e9535726ade294d3e13f0999f04c9c0893b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acute Kidney Injury - blood</topic><topic>Acute Kidney Injury - diagnosis</topic><topic>Acute Kidney Injury - mortality</topic><topic>Aged</topic><topic>Albumin</topic><topic>Biomarkers - blood</topic><topic>Cohort analysis</topic><topic>Dehydrogenases</topic><topic>Female</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Kidneys</topic><topic>L-Lactate dehydrogenase</topic><topic>L-Lactate Dehydrogenase - blood</topic><topic>Lactic acid</topic><topic>Male</topic><topic>Malignancy</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Nephrology</topic><topic>Original Article</topic><topic>Patients</topic><topic>Regression analysis</topic><topic>Renal function</topic><topic>Renal Replacement Therapy</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Sepsis</topic><topic>Sepsis - blood</topic><topic>Sepsis - complications</topic><topic>Serum Albumin, Human - analysis</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Weigan</creatorcontrib><creatorcontrib>Huo, Jianyang</creatorcontrib><creatorcontrib>Hu, Qiaohua</creatorcontrib><creatorcontrib>Xu, Jingtao</creatorcontrib><creatorcontrib>Chen, Guojun</creatorcontrib><creatorcontrib>Mo, Jierong</creatorcontrib><creatorcontrib>Zhou, Tianen</creatorcontrib><creatorcontrib>Jiang, Jun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Weigan</au><au>Huo, Jianyang</au><au>Hu, Qiaohua</au><au>Xu, Jingtao</au><au>Chen, Guojun</au><au>Mo, Jierong</au><au>Zhou, Tianen</au><au>Jiang, Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between lactate dehydrogenase to albumin ratio and acute kidney injury in patients with sepsis: a retrospective cohort study</atitle><jtitle>Clinical and experimental nephrology</jtitle><stitle>Clin Exp Nephrol</stitle><addtitle>Clin Exp Nephrol</addtitle><date>2024-09-01</date><risdate>2024</risdate><volume>28</volume><issue>9</issue><spage>882</spage><epage>893</epage><pages>882-893</pages><issn>1342-1751</issn><issn>1437-7799</issn><eissn>1437-7799</eissn><abstract>Background
Serum lactate dehydrogenase to albumin ratio (LAR) is associated with poor outcomes in malignancy and pneumonia. However, there are few studies suggesting that LAR is associated with the occurrence of acute kidney injury (AKI) in patients with sepsis, which was investigated in this study.
Methods
We conducted a retrospective cohort study based on the Medical Information Mart for Intensive Care (MIMIC)-IV database. The primary outcome was the occurrence of AKI within 2 days and 7 days. Multivariable logistic regression models were used to calculate odds ratios to validate the association between LAR and AKI, in-hospital mortality, RRT use, and recovery of renal function, respectively.
Results
A total of 4010 participants were included in this study. The median age of the participants was 63.5 years and the median LAR was 10.5. After adjusting for confounding variables, patients in the highest LAR quartile had a higher risk of AKI than those in the lowest LAR quartile within 2 days and 7 days, with odds ratios of 1.37 (95% confidence interval [CI]: 1.23–1.52) and 1.95 (95% CI: 1.72–2.22), respectively. The adjusted odds of AKI within 2 and 7 days were 1.16 (95% CI: 1.12–1.20) and 1.29 (95% CI: 1.24–1.35) for each 1 unit increase in LAR(log
2
), respectively.
Conclusion
This study demonstrated that elevated LAR was associated with poor prognosis in patients with sepsis. The risk of AKI and in-hospital mortality increased, the need for RRT increased, and the chance of recovery of renal function decreased with the increase of LAR.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><pmid>38584195</pmid><doi>10.1007/s10157-024-02500-y</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-4440-7246</orcidid></addata></record> |
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| subjects | Acute Kidney Injury - blood Acute Kidney Injury - diagnosis Acute Kidney Injury - mortality Aged Albumin Biomarkers - blood Cohort analysis Dehydrogenases Female Hospital Mortality Humans Kidneys L-Lactate dehydrogenase L-Lactate Dehydrogenase - blood Lactic acid Male Malignancy Medicine Medicine & Public Health Middle Aged Mortality Nephrology Original Article Patients Regression analysis Renal function Renal Replacement Therapy Retrospective Studies Risk Factors Sepsis Sepsis - blood Sepsis - complications Serum Albumin, Human - analysis Urology |
| title | Association between lactate dehydrogenase to albumin ratio and acute kidney injury in patients with sepsis: a retrospective cohort study |
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