Discovery of Highly Potent Solute Carrier 13 Member 5 (SLC13A5) Inhibitors for the Treatment of Hyperlipidemia

In the face of escalating metabolic disease prevalence, largely driven by modern lifestyle factors, this study addresses the critical need for novel therapeutic approaches. We have identified the sodium-coupled citrate transporter (NaCT or SLC13A5) as a target for intervention. Utilizing rational dr...

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Veröffentlicht in:Journal of medicinal chemistry 2024-04, Vol.67 (8), p.6687-6704
Hauptverfasser: Zhang, Li’ao, Hu, Wenjun, Guo, Huimin, Sun, Qiushuang, Xu, Xi, Li, Zhiyu, Qiu, Zhixia, Bian, Jinlei
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Sprache:eng
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