Emerging threat: Antimicrobial resistance proliferation during epidemics — A case study of the SARS-CoV-2 pandemic in South Brazil
The escalating global concern of antimicrobial resistance poses a significant challenge to public health. This study delved into the occurrence of resistant bacteria and antimicrobial resistance genes in the waters and sediments of urban rivers and correlated this emergence and the heightened use of...
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| Veröffentlicht in: | Journal of hazardous materials 2024-05, Vol.470, p.134202, Article 134202 |
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| creator | Marques, Raizza Zorman da Silva Nogueira, Keite de Oliveira Tomaz, Ana Paula Juneau, Philippe Wang, Shanquan Gomes, Marcelo Pedrosa |
| description | The escalating global concern of antimicrobial resistance poses a significant challenge to public health. This study delved into the occurrence of resistant bacteria and antimicrobial resistance genes in the waters and sediments of urban rivers and correlated this emergence and the heightened use of antimicrobials during the COVID-19 pandemic. Isolating 45 antimicrobial-resistant bacteria across 11 different species, the study identifies prevalent resistance patterns, with ceftriaxone resistance observed in 18 isolates and ciprofloxacin resistance observed in 13 isolates. The detection of extended-spectrum β-lactamases, carbapenemases, and acquired quinolone resistance genes in all samples underscores the gravity of the situation. Comparison with a pre-pandemic study conducted in the same rivers in 2019 reveals the emergence of previously undetected new resistant species, and the noteworthy presence of new resistant species and alterations in resistance profiles among existing species. Notably, antimicrobial concentrations in rivers increased during the pandemic, contributing significantly to the scenario of antimicrobial resistance observed in these rivers. We underscore the substantial impact of heightened antimicrobial usage during epidemics, such as COVID-19, on resistance in urban rivers. It provides valuable insights into the complex dynamics of antimicrobial resistance in environmental settings and calls for comprehensive approaches to combat this pressing global health issue, safeguarding both public and environmental health.
[Display omitted]
•Antimicrobial resistance genes and resistant bacteria were investigated in urban rivers.•Genes conferring resistance to carbapenems and polymyxin were detected in environmental samples.•We correlated antimicrobial concentrations with resistance profiles in rivers.•The COVID-19 pandemic impacted the antimicrobial resistance in urban rivers of South Brazil. |
| doi_str_mv | 10.1016/j.jhazmat.2024.134202 |
| format | Article |
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[Display omitted]
•Antimicrobial resistance genes and resistant bacteria were investigated in urban rivers.•Genes conferring resistance to carbapenems and polymyxin were detected in environmental samples.•We correlated antimicrobial concentrations with resistance profiles in rivers.•The COVID-19 pandemic impacted the antimicrobial resistance in urban rivers of South Brazil.</description><identifier>ISSN: 0304-3894</identifier><identifier>ISSN: 1873-3336</identifier><identifier>EISSN: 1873-3336</identifier><identifier>DOI: 10.1016/j.jhazmat.2024.134202</identifier><identifier>PMID: 38581873</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Anti-Bacterial Agents - pharmacology ; Antibiotic ; Bacteria - drug effects ; Bacteria - genetics ; Brazil - epidemiology ; Comprehensive approaches ; COVID-19 - epidemiology ; Drug Resistance, Bacterial ; Genes ; Humans ; Pandemics ; Public health ; Rivers - microbiology ; SARS-CoV-2 - drug effects</subject><ispartof>Journal of hazardous materials, 2024-05, Vol.470, p.134202, Article 134202</ispartof><rights>2024 Elsevier B.V.</rights><rights>Copyright © 2024 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-8c41a4be3e87885dead0e1fa33c835e4606a4e81354f7d7383264800c6fa85543</citedby><cites>FETCH-LOGICAL-c365t-8c41a4be3e87885dead0e1fa33c835e4606a4e81354f7d7383264800c6fa85543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304389424007817$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38581873$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marques, Raizza Zorman</creatorcontrib><creatorcontrib>da Silva Nogueira, Keite</creatorcontrib><creatorcontrib>de Oliveira Tomaz, Ana Paula</creatorcontrib><creatorcontrib>Juneau, Philippe</creatorcontrib><creatorcontrib>Wang, Shanquan</creatorcontrib><creatorcontrib>Gomes, Marcelo Pedrosa</creatorcontrib><title>Emerging threat: Antimicrobial resistance proliferation during epidemics — A case study of the SARS-CoV-2 pandemic in South Brazil</title><title>Journal of hazardous materials</title><addtitle>J Hazard Mater</addtitle><description>The escalating global concern of antimicrobial resistance poses a significant challenge to public health. This study delved into the occurrence of resistant bacteria and antimicrobial resistance genes in the waters and sediments of urban rivers and correlated this emergence and the heightened use of antimicrobials during the COVID-19 pandemic. Isolating 45 antimicrobial-resistant bacteria across 11 different species, the study identifies prevalent resistance patterns, with ceftriaxone resistance observed in 18 isolates and ciprofloxacin resistance observed in 13 isolates. The detection of extended-spectrum β-lactamases, carbapenemases, and acquired quinolone resistance genes in all samples underscores the gravity of the situation. Comparison with a pre-pandemic study conducted in the same rivers in 2019 reveals the emergence of previously undetected new resistant species, and the noteworthy presence of new resistant species and alterations in resistance profiles among existing species. Notably, antimicrobial concentrations in rivers increased during the pandemic, contributing significantly to the scenario of antimicrobial resistance observed in these rivers. We underscore the substantial impact of heightened antimicrobial usage during epidemics, such as COVID-19, on resistance in urban rivers. It provides valuable insights into the complex dynamics of antimicrobial resistance in environmental settings and calls for comprehensive approaches to combat this pressing global health issue, safeguarding both public and environmental health.
[Display omitted]
•Antimicrobial resistance genes and resistant bacteria were investigated in urban rivers.•Genes conferring resistance to carbapenems and polymyxin were detected in environmental samples.•We correlated antimicrobial concentrations with resistance profiles in rivers.•The COVID-19 pandemic impacted the antimicrobial resistance in urban rivers of South Brazil.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotic</subject><subject>Bacteria - drug effects</subject><subject>Bacteria - genetics</subject><subject>Brazil - epidemiology</subject><subject>Comprehensive approaches</subject><subject>COVID-19 - epidemiology</subject><subject>Drug Resistance, Bacterial</subject><subject>Genes</subject><subject>Humans</subject><subject>Pandemics</subject><subject>Public health</subject><subject>Rivers - microbiology</subject><subject>SARS-CoV-2 - drug effects</subject><issn>0304-3894</issn><issn>1873-3336</issn><issn>1873-3336</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1OGzEUhS1UVAL0Eai87GZSe649Y7pBaUQpElIlQru1HPsOcTQ_qe2pBCsWfYQ-YZ8Eh4Ruuzqb79yrcw4hZ5xNOePVx_V0vTKPnUnTkpViykFkPSATrmooAKB6QyYMmChAnYsjchzjmjHGaynekiNQUm3BCfl92WG49_09TauAJn2isz75ztswLL1pacDoYzK9RboJQ-sbDCb5oaduDFsXbrzDjEf69-kPnVFrItKYRvdAhybfRLqY3S6K-fCjKOnG9C8w9T1dDGNa0c_BPPr2lBw2po34bq8n5PuXy7v51-Lm29X1fHZTWKhkKpQV3IglAqpaKenQOIa8MQBWgURRscoIVBykaGpXg4KyEooxWzVGSSnghHzY3c1Rfo4Yk-58tNi2psdhjBpYblHUdXmeUblDcxExBmz0JvjOhAfNmd4OoNd6P4DeDqB3A2Tf-_2Lcdmh--d6bTwDFzsAc9BfHoOO1mPu1_mANmk3-P-8eAawUpqq</recordid><startdate>20240515</startdate><enddate>20240515</enddate><creator>Marques, Raizza Zorman</creator><creator>da Silva Nogueira, Keite</creator><creator>de Oliveira Tomaz, Ana Paula</creator><creator>Juneau, Philippe</creator><creator>Wang, Shanquan</creator><creator>Gomes, Marcelo Pedrosa</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240515</creationdate><title>Emerging threat: Antimicrobial resistance proliferation during epidemics — A case study of the SARS-CoV-2 pandemic in South Brazil</title><author>Marques, Raizza Zorman ; da Silva Nogueira, Keite ; de Oliveira Tomaz, Ana Paula ; Juneau, Philippe ; Wang, Shanquan ; Gomes, Marcelo Pedrosa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-8c41a4be3e87885dead0e1fa33c835e4606a4e81354f7d7383264800c6fa85543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotic</topic><topic>Bacteria - drug effects</topic><topic>Bacteria - genetics</topic><topic>Brazil - epidemiology</topic><topic>Comprehensive approaches</topic><topic>COVID-19 - epidemiology</topic><topic>Drug Resistance, Bacterial</topic><topic>Genes</topic><topic>Humans</topic><topic>Pandemics</topic><topic>Public health</topic><topic>Rivers - microbiology</topic><topic>SARS-CoV-2 - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marques, Raizza Zorman</creatorcontrib><creatorcontrib>da Silva Nogueira, Keite</creatorcontrib><creatorcontrib>de Oliveira Tomaz, Ana Paula</creatorcontrib><creatorcontrib>Juneau, Philippe</creatorcontrib><creatorcontrib>Wang, Shanquan</creatorcontrib><creatorcontrib>Gomes, Marcelo Pedrosa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hazardous materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marques, Raizza Zorman</au><au>da Silva Nogueira, Keite</au><au>de Oliveira Tomaz, Ana Paula</au><au>Juneau, Philippe</au><au>Wang, Shanquan</au><au>Gomes, Marcelo Pedrosa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Emerging threat: Antimicrobial resistance proliferation during epidemics — A case study of the SARS-CoV-2 pandemic in South Brazil</atitle><jtitle>Journal of hazardous materials</jtitle><addtitle>J Hazard Mater</addtitle><date>2024-05-15</date><risdate>2024</risdate><volume>470</volume><spage>134202</spage><pages>134202-</pages><artnum>134202</artnum><issn>0304-3894</issn><issn>1873-3336</issn><eissn>1873-3336</eissn><abstract>The escalating global concern of antimicrobial resistance poses a significant challenge to public health. This study delved into the occurrence of resistant bacteria and antimicrobial resistance genes in the waters and sediments of urban rivers and correlated this emergence and the heightened use of antimicrobials during the COVID-19 pandemic. Isolating 45 antimicrobial-resistant bacteria across 11 different species, the study identifies prevalent resistance patterns, with ceftriaxone resistance observed in 18 isolates and ciprofloxacin resistance observed in 13 isolates. The detection of extended-spectrum β-lactamases, carbapenemases, and acquired quinolone resistance genes in all samples underscores the gravity of the situation. Comparison with a pre-pandemic study conducted in the same rivers in 2019 reveals the emergence of previously undetected new resistant species, and the noteworthy presence of new resistant species and alterations in resistance profiles among existing species. Notably, antimicrobial concentrations in rivers increased during the pandemic, contributing significantly to the scenario of antimicrobial resistance observed in these rivers. We underscore the substantial impact of heightened antimicrobial usage during epidemics, such as COVID-19, on resistance in urban rivers. It provides valuable insights into the complex dynamics of antimicrobial resistance in environmental settings and calls for comprehensive approaches to combat this pressing global health issue, safeguarding both public and environmental health.
[Display omitted]
•Antimicrobial resistance genes and resistant bacteria were investigated in urban rivers.•Genes conferring resistance to carbapenems and polymyxin were detected in environmental samples.•We correlated antimicrobial concentrations with resistance profiles in rivers.•The COVID-19 pandemic impacted the antimicrobial resistance in urban rivers of South Brazil.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>38581873</pmid><doi>10.1016/j.jhazmat.2024.134202</doi></addata></record> |
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| subjects | Anti-Bacterial Agents - pharmacology Antibiotic Bacteria - drug effects Bacteria - genetics Brazil - epidemiology Comprehensive approaches COVID-19 - epidemiology Drug Resistance, Bacterial Genes Humans Pandemics Public health Rivers - microbiology SARS-CoV-2 - drug effects |
| title | Emerging threat: Antimicrobial resistance proliferation during epidemics — A case study of the SARS-CoV-2 pandemic in South Brazil |
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