Impact of inflammation and steroids on anti-coagulation in children supported on a ventricular assist device

Critically ill pediatric patients supported on ventricular assist devices (VADs) are increasingly being anticoagulated on bivalirudin, but with difficulty monitoring anticoagulation. Activated partial thromboplastin time (aPTT) has recently been shown to poorly correlate with bivalirudin plasma conc...

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Veröffentlicht in:	Journal of artificial organs 2024-12, Vol.27 (4), p.368-374
Hauptverfasser:	Brandewie, Katie, Lorts, Angela, Luchtman-Jones, Lori, Gao, Zhiqian, Geer, Becca, Villa, Chet, Perry, Tanya
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticoagulants Anticoagulants - therapeutic use Biomedical Engineering and Bioengineering Blood Coagulation - drug effects Blood Coagulation - physiology Cardiac Surgery Child, Preschool Children Coagulation Correlation Dithiothreitol Female Health care facilities Heart-Assist Devices - adverse effects Hirudins Humans Infant Infections Inflammation Inflammation - blood Male Medicine Medicine & Public Health Monitoring Nephrology Original Article Partial Thromboplastin Time Patients Pediatrics Peptide Fragments - blood Peptide Fragments - therapeutic use Recombinant Proteins - therapeutic use Retrospective Studies Steroid hormones Steroids Steroids - therapeutic use Telemedicine Thromboplastin Ventricle Ventricular assist devices
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