ASH2L Mediates Epidermal Differentiation and Hair Follicle Morphogenesis through H3K4me3 Modification

The processes of epidermal development in mammals are regulated by complex molecular mechanisms, such as histone modifications. Histone H3 lysine K4 methylation mediated by COMPASS (complex of proteins associated with Set1) methyltransferase is associated with gene activation, but its effect on epid...

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Veröffentlicht in:	Journal of investigative dermatology 2024-11, Vol.144 (11), p.2406-2416.e10
Hauptverfasser:	Wang, Qirui, Zeng, Siyi, Liang, Yimin, Zhou, Renpeng, Wang, Danru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ASH2L Cell Differentiation Epidermal Cells - cytology Epidermal Cells - metabolism Epidermal development Epidermis - metabolism Epigenesis, Genetic H3K4me3 Hair Follicle - cytology Hair Follicle - growth & development Hair Follicle - metabolism Hair follicle morphogenesis Histone-Lysine N-Methyltransferase - genetics Histone-Lysine N-Methyltransferase - metabolism Histones - metabolism Mice Mice, Knockout Morphogenesis Signal Transduction Stem Cells - cytology Stem Cells - metabolism
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