E3 Ubiquitin Ligase NEDD4L Negatively Regulates Skin Tumorigenesis by Inhibiting IL-6/GP130 Signaling Pathway

IL-6 signaling plays a crucial role in the survival and metastasis of skin cancer. NEDD4L acts as a suppressor of IL-6 signaling by targeting GP130 degradation. However, the effects of the NEDD4L-regulated IL-6/GP130 signaling pathway on skin cancer remain unclear. In this study, protein expression...

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Veröffentlicht in:	Journal of investigative dermatology 2024-11, Vol.144 (11), p.2453-2464.e11
Hauptverfasser:	Liu, Huan, Wang, Ning, Yang, Run, Luan, Jing, Cao, Meng, Zhai, Cui, Wang, Shan, Wei, Mengqian, Wang, Duorong, Qiao, Jiayue, Liu, Yuqian, She, Wenting, Guo, Na, Liao, Bo, Gou, Xingchun
Format:	Artikel
Sprache:	eng
Schlagworte:	GP130 NEDD4L SC144 Skin cancer Ubiquitination
Online-Zugang:	Volltext
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