Edaravone dexborneol attenuates cognitive impairment in a rat model of vascular dementia by inhibiting hippocampal oxidative stress and inflammatory responses and modulating the NMDA receptor signaling pathway

[Display omitted] •EDB can reduce nerve injury and improve cognitive ability.•EDB can alleviate inflammatory response and oxidative stress.•EDB can regulate NMDA receptor signaling pathway.•Supplemented the mechanism of action of EDB in treating VD. Exploring the intricate pathogenesis of Vascular D...

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Veröffentlicht in:	Brain research 2024-06, Vol.1833, p.148917-148917, Article 148917
Hauptverfasser:	Guo, Hui, Li, Haodong, Jia, Zhisheng, Ma, Shuyu, Zhang, Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cognitive Dysfunction - drug therapy Cognitive Dysfunction - metabolism Cognitive impairment Dementia, Vascular - drug therapy Dementia, Vascular - metabolism Disease Models, Animal Edaravone - pharmacology Edaravone dexborneol Hippocampus - drug effects Hippocampus - metabolism Inflammation - drug therapy Inflammation - metabolism Inflammatory response Male Neuroprotective Agents - pharmacology NMDA receptor signaling pathway Oxidative stress Oxidative Stress - drug effects Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - metabolism Signal Transduction - drug effects Vascular dementia
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