Oral Formulation of 5-Aminosalicylic Acid-Hemoglobin Bio-Adhesive Nanoparticles Enhance Therapeutic Efficiency in Ulcerative Colitis Mice: A Preclinical Evaluation

•In vivo-evaluated 5-ASA-HbNPs as a colon-specific prodrug for treatment of experimental colitis.•HbNPs conjugation is an efficient way to increase the therapeutic effect and to reduce the adverse effects of 5-ASA.•HbNPs acted as not only a pro-moiety but also a therapeutically active agent.•Mucoadh...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2024-08, Vol.113 (8), p.2331-2341
Hauptverfasser:	Vaezi, Zahra, Baradaran Ghavami, Shaghayegh, Farmani, Maryam, Mahdavian, Reza, Asadzadeh Aghdaei, Hamid, Naderi-Manesh, Hossein
Format:	Artikel
Sprache:	eng
Schlagworte:	5-aminosalicylic acid Administration, Oral Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Anti-Inflammatory Agents, Non-Steroidal - pharmacology Colitis, Ulcerative - drug therapy Colitis, Ulcerative - metabolism Colon - drug effects Colon - metabolism Colon - pathology Colon-specific delivery Disease Models, Animal Drug Carriers - chemistry Drug Delivery Systems - methods Hemoglobin nanoparticles Hemoglobins - administration & dosage Male Mesalamine - administration & dosage Mesalamine - chemistry Mesalamine - pharmacology Mice Mucus adhesion Nanoparticles - chemistry Oral administration Ulcerative colitis
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