The relationship between serum astroglial and neuronal markers and AQP4 and MOG autoantibodies
Certain demyelinating disorders, such as neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) exhibit serum autoantibodies against aquaporin-4 (αAQP4) and myelin oligodendrocyte glycoprotein (αMOG). The variability of the autoanti...
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| Veröffentlicht in: | Clinical proteomics 2024-04, Vol.21 (1), p.28-28, Article 28 |
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| creator | Chatanaka, Miyo K Avery, Lisa M Pasic, Maria D Sithravadivel, Shanthan Rotstein, Dalia Demos, Catherine Cohen, Rachel Gorham, Taron Wang, Mingyue Stengelin, Martin Mathew, Anu Sigal, George Wohlstadter, Jacob Prassas, Ioannis Diamandis, Eleftherios P |
| description | Certain demyelinating disorders, such as neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) exhibit serum autoantibodies against aquaporin-4 (αAQP4) and myelin oligodendrocyte glycoprotein (αMOG). The variability of the autoantibody presentation warrants further research into subtyping each case.
To elucidate the relationship between astroglial and neuronal protein concentrations in the peripheral circulation with occurrence of these autoantibodies, 86 serum samples were analyzed using immunoassays. The protein concentration of glial fibrillary acidic protein (GFAP), neurofilament light chain (NFL) and tau protein was measured in 3 groups of subcategories of suspected NMOSD: αAQP4 positive (n = 20), αMOG positive (n = 32) and αMOG/αAQP4 seronegative (n = 34). Kruskal-Wallis analysis, univariate predictor analysis, and multivariate logistic regression with ROC curves were performed.
GFAP and NFL concentrations were significantly elevated in the αAQP4 positive group (p = 0.003; p = 0.042, respectively), and tau was elevated in the αMOG/αAQP4 seronegative group (p |
| doi_str_mv | 10.1186/s12014-024-09466-9 |
| format | Article |
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To elucidate the relationship between astroglial and neuronal protein concentrations in the peripheral circulation with occurrence of these autoantibodies, 86 serum samples were analyzed using immunoassays. The protein concentration of glial fibrillary acidic protein (GFAP), neurofilament light chain (NFL) and tau protein was measured in 3 groups of subcategories of suspected NMOSD: αAQP4 positive (n = 20), αMOG positive (n = 32) and αMOG/αAQP4 seronegative (n = 34). Kruskal-Wallis analysis, univariate predictor analysis, and multivariate logistic regression with ROC curves were performed.
GFAP and NFL concentrations were significantly elevated in the αAQP4 positive group (p = 0.003; p = 0.042, respectively), and tau was elevated in the αMOG/αAQP4 seronegative group (p < 0.001). A logistic regression model to classify serostatus was able to separate αAQP4 seropositivity using GFAP + tau, and αMOG seropositivity using tau. The areas under the ROC curves (AUCs) were 0.77 and 0.72, respectively. Finally, a combined seropositivity versus negative status logistic regression model was generated, with AUC = 0.80.
The 3 markers can univariately and multivariately classify with moderate accuracy the samples with seropositivity and seronegativity for αAQP4 and αMOG.</description><identifier>ISSN: 1542-6416</identifier><identifier>EISSN: 1559-0275</identifier><identifier>DOI: 10.1186/s12014-024-09466-9</identifier><identifier>PMID: 38580905</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Aquaporin 4 ; Aquaporins ; Autoantibodies ; Autoimmunity ; Biomarkers ; Demyelinating diseases ; Demyelination ; Disease ; Glial fibrillary acidic protein ; Glycoproteins ; Immunoassay ; Immunoassays ; Laboratories ; Myelin ; Myelin proteins ; Neuromyelitis ; Neuronal-glial interactions ; Neurons ; Oligodendrocyte-myelin glycoprotein ; Patients ; Proteins ; Regression analysis ; Tau protein</subject><ispartof>Clinical proteomics, 2024-04, Vol.21 (1), p.28-28, Article 28</ispartof><rights>2024. The Author(s).</rights><rights>COPYRIGHT 2024 BioMed Central Ltd.</rights><rights>2024. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c424t-bcf7d6ac983016ce09803cf0631f1712dcd3d9f3422d14372d67bcc5c081ea7f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38580905$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chatanaka, Miyo K</creatorcontrib><creatorcontrib>Avery, Lisa M</creatorcontrib><creatorcontrib>Pasic, Maria D</creatorcontrib><creatorcontrib>Sithravadivel, Shanthan</creatorcontrib><creatorcontrib>Rotstein, Dalia</creatorcontrib><creatorcontrib>Demos, Catherine</creatorcontrib><creatorcontrib>Cohen, Rachel</creatorcontrib><creatorcontrib>Gorham, Taron</creatorcontrib><creatorcontrib>Wang, Mingyue</creatorcontrib><creatorcontrib>Stengelin, Martin</creatorcontrib><creatorcontrib>Mathew, Anu</creatorcontrib><creatorcontrib>Sigal, George</creatorcontrib><creatorcontrib>Wohlstadter, Jacob</creatorcontrib><creatorcontrib>Prassas, Ioannis</creatorcontrib><creatorcontrib>Diamandis, Eleftherios P</creatorcontrib><title>The relationship between serum astroglial and neuronal markers and AQP4 and MOG autoantibodies</title><title>Clinical proteomics</title><addtitle>Clin Proteomics</addtitle><description>Certain demyelinating disorders, such as neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) exhibit serum autoantibodies against aquaporin-4 (αAQP4) and myelin oligodendrocyte glycoprotein (αMOG). The variability of the autoantibody presentation warrants further research into subtyping each case.
To elucidate the relationship between astroglial and neuronal protein concentrations in the peripheral circulation with occurrence of these autoantibodies, 86 serum samples were analyzed using immunoassays. The protein concentration of glial fibrillary acidic protein (GFAP), neurofilament light chain (NFL) and tau protein was measured in 3 groups of subcategories of suspected NMOSD: αAQP4 positive (n = 20), αMOG positive (n = 32) and αMOG/αAQP4 seronegative (n = 34). Kruskal-Wallis analysis, univariate predictor analysis, and multivariate logistic regression with ROC curves were performed.
GFAP and NFL concentrations were significantly elevated in the αAQP4 positive group (p = 0.003; p = 0.042, respectively), and tau was elevated in the αMOG/αAQP4 seronegative group (p < 0.001). A logistic regression model to classify serostatus was able to separate αAQP4 seropositivity using GFAP + tau, and αMOG seropositivity using tau. The areas under the ROC curves (AUCs) were 0.77 and 0.72, respectively. Finally, a combined seropositivity versus negative status logistic regression model was generated, with AUC = 0.80.
The 3 markers can univariately and multivariately classify with moderate accuracy the samples with seropositivity and seronegativity for αAQP4 and αMOG.</description><subject>Aquaporin 4</subject><subject>Aquaporins</subject><subject>Autoantibodies</subject><subject>Autoimmunity</subject><subject>Biomarkers</subject><subject>Demyelinating diseases</subject><subject>Demyelination</subject><subject>Disease</subject><subject>Glial fibrillary acidic protein</subject><subject>Glycoproteins</subject><subject>Immunoassay</subject><subject>Immunoassays</subject><subject>Laboratories</subject><subject>Myelin</subject><subject>Myelin proteins</subject><subject>Neuromyelitis</subject><subject>Neuronal-glial interactions</subject><subject>Neurons</subject><subject>Oligodendrocyte-myelin glycoprotein</subject><subject>Patients</subject><subject>Proteins</subject><subject>Regression analysis</subject><subject>Tau 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Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical proteomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chatanaka, Miyo K</au><au>Avery, Lisa M</au><au>Pasic, Maria D</au><au>Sithravadivel, Shanthan</au><au>Rotstein, Dalia</au><au>Demos, Catherine</au><au>Cohen, Rachel</au><au>Gorham, Taron</au><au>Wang, Mingyue</au><au>Stengelin, Martin</au><au>Mathew, Anu</au><au>Sigal, George</au><au>Wohlstadter, Jacob</au><au>Prassas, Ioannis</au><au>Diamandis, Eleftherios P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between serum astroglial and neuronal markers and AQP4 and MOG autoantibodies</atitle><jtitle>Clinical proteomics</jtitle><addtitle>Clin Proteomics</addtitle><date>2024-04-05</date><risdate>2024</risdate><volume>21</volume><issue>1</issue><spage>28</spage><epage>28</epage><pages>28-28</pages><artnum>28</artnum><issn>1542-6416</issn><eissn>1559-0275</eissn><abstract>Certain demyelinating disorders, such as neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) exhibit serum autoantibodies against aquaporin-4 (αAQP4) and myelin oligodendrocyte glycoprotein (αMOG). The variability of the autoantibody presentation warrants further research into subtyping each case.
To elucidate the relationship between astroglial and neuronal protein concentrations in the peripheral circulation with occurrence of these autoantibodies, 86 serum samples were analyzed using immunoassays. The protein concentration of glial fibrillary acidic protein (GFAP), neurofilament light chain (NFL) and tau protein was measured in 3 groups of subcategories of suspected NMOSD: αAQP4 positive (n = 20), αMOG positive (n = 32) and αMOG/αAQP4 seronegative (n = 34). Kruskal-Wallis analysis, univariate predictor analysis, and multivariate logistic regression with ROC curves were performed.
GFAP and NFL concentrations were significantly elevated in the αAQP4 positive group (p = 0.003; p = 0.042, respectively), and tau was elevated in the αMOG/αAQP4 seronegative group (p < 0.001). A logistic regression model to classify serostatus was able to separate αAQP4 seropositivity using GFAP + tau, and αMOG seropositivity using tau. The areas under the ROC curves (AUCs) were 0.77 and 0.72, respectively. Finally, a combined seropositivity versus negative status logistic regression model was generated, with AUC = 0.80.
The 3 markers can univariately and multivariately classify with moderate accuracy the samples with seropositivity and seronegativity for αAQP4 and αMOG.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>38580905</pmid><doi>10.1186/s12014-024-09466-9</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aquaporin 4 Aquaporins Autoantibodies Autoimmunity Biomarkers Demyelinating diseases Demyelination Disease Glial fibrillary acidic protein Glycoproteins Immunoassay Immunoassays Laboratories Myelin Myelin proteins Neuromyelitis Neuronal-glial interactions Neurons Oligodendrocyte-myelin glycoprotein Patients Proteins Regression analysis Tau protein |
| title | The relationship between serum astroglial and neuronal markers and AQP4 and MOG autoantibodies |
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