Metabolic Heterogeneity and Potential Immunotherapeutic Responses Revealed by Single-Cell Transcriptomics of Breast Cancer

Background Breast cancer (BC) exhibits remarkable heterogeneity. However, the transcriptomic heterogeneity of BC at the single-cell level has not been fully elucidated. Methods We acquired BC samples from 14 patients. Single-cell RNA sequencing (scRNA-seq), bioinformatic analyses, along with immunoh...

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Veröffentlicht in:	Apoptosis (London) 2024-10, Vol.29 (9-10), p.1466-1482
Hauptverfasser:	Tang, Shicong, Wang, Qing, Sun, Ke, Song, Ying, Liu, Rui, Tan, Xin, Li, Huimeng, Lv, Yafeng, Yang, Fuying, Zhao, Jiawen, Li, Sijia, Bi, Pingping, Yang, Jiali, Zhu, Zhengna, Chen, Dong, Chuan, Zhirui, Luo, Xiaomao, Hu, Zaoxiu, Liu, Ying, Li, Zhenhui, Ke, Tengfei, Jiang, Dewei, Zheng, Kai, Yang, Rirong, Chen, Kai, Guo, Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid resistance Analysis B cells Biochemistry Biomedical and Life Sciences Biomedicine Breast cancer Cancer Cancer Research Cell Biology Chemoresistance Chemotherapy Fatty acids Gene sequencing Gluconeogenesis Glycolysis Heterogeneity Immunofluorescence Immunohistochemistry Immunotherapy Ligases Lymphocytes Lymphocytes T Metabolism Metastases Metastasis Oncology Predictions RNA RNA sequencing T cells Transcriptomics Tumor cells Tumors Virology
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