Memantine suppresses the excitotoxicity but fails to rescue the ataxic phenotype in SCA1 model mice

Spinocerebellar ataxia type 1 (SCA1) is a debilitating neurodegenerative disorder of the cerebellum and brainstem. Memantine has been proposed as a potential treatment for SCA1. It blocks N-methyl-D-aspartate (NMDA) receptors on neurons, reduces excitotoxicity and decreases neurodegeneration in Alzh...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2024-05, Vol.174, p.116526-116526, Article 116526
Hauptverfasser:	Belozor, Olga S., Vasilev, Alex, Mileiko, Alexandra G., Mosina, Lyudmila D., Mikhailov, Ilya G., Ox, Darius A., Boitsova, Elizaveta B., Shuvaev, Andrey N., Teschemacher, Anja G., Kasparov, Sergey, Shuvaev, Anton N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bergmann glia Memantine Neurodegeneration Spinocerebellar ataxia type 1
Online-Zugang:	Volltext
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