Development of (2-(Benzyloxy)phenyl)methanamine Derivatives as Potent and Selective Inhibitors of CARM1 for the Treatment of Melanoma

Coactivator-associated arginine methyltransferase 1 (CARM1), an important member of type I protein arginine methyltransferases (PRMTs), has emerged as a promising therapeutic target for various cancer types. In our previous study, we have identified a series of type I PRMT inhibitors, among which ZL...

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Veröffentlicht in:	Journal of medicinal chemistry 2024-04, Vol.67 (8), p.6313-6326
Hauptverfasser:	Liu, Zhihao, Lin, Min, Liu, Chenyu, Chen, Xin, Chen, Qian, Li, Xinyu, Wu, Xiaoyan, Wang, Yahui, Wang, Lei, Yang, Fan, Luo, Cheng, Jin, Jia, Ye, Fei
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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