N6022 attenuates cerebral ischemia/reperfusion injury-induced microglia ferroptosis by promoting Nrf2 nuclear translocation and inhibiting the GSNOR/GSTP1 axis

Stroke poses a significant risk of mortality, particularly among the elderly population. The pathophysiological process of ischemic stroke is complex, and it is crucial to elucidate its molecular mechanisms and explore potential protective drugs. Ferroptosis, a newly recognized form of programmed ce...

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Veröffentlicht in:	European journal of pharmacology 2024-06, Vol.972, p.176553-176553, Article 176553
Hauptverfasser:	Duan, Wan-Li, Ma, Ya-Ping, Wang, Xue-Jie, Ma, Chang-Sheng, Han, Bo, Sheng, Zhi-Mei, Dong, Hao, Zhang, Li-Ying, Li, P. Andy, Zhang, Bao-Gang, He, Mao-Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Cerebral ischemia/reperfusion injury Ferroptosis GSNOR/GSTP1 axis Microglia N6022 Nrf2 nuclear translocation
Online-Zugang:	Volltext
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