Telomere dysfunction alters intestinal stem cell dynamics to promote cancer

Telomere dynamics are linked to aging hallmarks, and age-associated telomere loss fuels the development of epithelial cancers. In Apc-mutant mice, the onset of DNA damage associated with telomere dysfunction has been shown to accelerate adenoma initiation via unknown mechanisms. Here, we observed th...

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Veröffentlicht in:	Developmental cell 2024-06, Vol.59 (11), p.1475-1486.e5
Hauptverfasser:	LaBella, Kyle A., Hsu, Wen-Hao, Li, Jiexi, Qi, Yutao, Liu, Yonghong, Liu, Jingjing, Wu, Chia-Chin, Liu, Yang, Song, Zingzhi, Lin, Yiyun, Blecher, Jonathan M., Jiang, Shan, Shang, Xiaoying, Han, Jincheng, Spring, Denise J., Zhang, Jianhua, Xia, Yan, DePinho, Ronald A.
Format:	Artikel
Sprache:	eng
Schlagworte:	colorectal cancer EZH2 genomic instability initiation microenvironment telomeres Wnt signaling
Online-Zugang:	Volltext
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