Robot-assisted versus laparoscopic pancreatoduodenectomy: a pan-European multicenter propensity-matched study
The use of robot-assisted and laparoscopic pancreatoduodenectomy is increasing, yet large adjusted analyses that can be generalized internationally are lacking. This study aimed to compare outcomes after robot-assisted pancreatoduodenectomy and laparoscopic pancreatoduodenectomy in a pan-European co...
Gespeichert in:
| Veröffentlicht in: | Surgery 2024-06, Vol.175 (6), p.1587-1594 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1594 |
|---|---|
| container_issue | 6 |
| container_start_page | 1587 |
| container_title | Surgery |
| container_volume | 175 |
| creator | Emmen, Anouk M.L.H. Zwart, Maurice J.W. Khatkov, Igor E. Boggi, Ugo Groot Koerkamp, Bas Busch, Olivier R. Saint-Marc, Olivier Dokmak, Safi Molenaar, I. Quintus D’Hondt, Mathieu Ramera, Marco Keck, Tobias Ferrari, Giovanni Luyer, Misha D.P. Moraldi, Luca Ielpo, Benedetto Wittel, Uwe Souche, Francois-Regis Hackert, Thilo Lips, Daan Can, Mehmet Fatih Bosscha, Koop Fara, Regis Festen, Sebastiaan van Dieren, Susan Coratti, Andrea De Hingh, Ignace Mazzola, Michele Wellner, Ulrich De Meyere, Celine van Santvoort, Hjalmar C. Aussilhou, Béatrice Ibenkhayat, Abdallah de Wilde, Roeland F. Kauffmann, Emanuele F. Tyutyunnik, Pavel Besselink, Marc G. Abu Hilal, Mohammad Manzoni, Alberto Guerra, Martina Daams, Freek Kazemier, Geert Izrailov, Roman Efanov, Mikhail Napoli, Niccolò Ginesini, Michael Cappelle, Marie Haen, Roel Quetel, Romain Pucci, Marco Derksen, Wouter Hagendoorn, Jeroen Ftériche, Fadhel Samir Muzzolini, Milena Vansteenkiste, Franky Bolm, Louisa Winkel, Maike ten Giani, Alessandro Calcagno, Pietro |
| description | The use of robot-assisted and laparoscopic pancreatoduodenectomy is increasing, yet large adjusted analyses that can be generalized internationally are lacking. This study aimed to compare outcomes after robot-assisted pancreatoduodenectomy and laparoscopic pancreatoduodenectomy in a pan-European cohort.
An international multicenter retrospective study including patients after robot-assisted pancreatoduodenectomy and laparoscopic pancreatoduodenectomy from 50 centers in 12 European countries (2009–2020). Propensity score matching was performed in a 1:1 ratio. The primary outcome was major morbidity (Clavien–Dindo ≥III).
Among 2,082 patients undergoing minimally invasive pancreatoduodenectomy, 1,006 underwent robot-assisted pancreatoduodenectomy and 1,076 laparoscopic pancreatoduodenectomy. After matching 812 versus 812 patients, the rates of major morbidity (31.9% vs 29.6%; P = .347) and 30-day/in-hospital mortality (4.3% vs 4.6%; P = .904) did not differ significantly between robot-assisted pancreatoduodenectomy and laparoscopic pancreatoduodenectomy, respectively. Robot-assisted pancreatoduodenectomy was associated with a lower conversion rate (6.7% vs 18.0%; P < .001) and higher lymph node retrieval (16 vs 14; P = .003). Laparoscopic pancreatoduodenectomy was associated with shorter operation time (446 minutes versus 400 minutes; P < .001), and lower rates of postoperative pancreatic fistula grade B/C (19.0% vs 11.7%; P < .001), delayed gastric emptying grade B/C (21.4% vs 7.4%; P < .001), and a higher R0-resection rate (73.2% vs 84.4%; P < .001).
This European multicenter study found no differences in overall major morbidity and 30-day/in-hospital mortality after robot-assisted pancreatoduodenectomy compared with laparoscopic pancreatoduodenectomy. Further, laparoscopic pancreatoduodenectomy was associated with a lower rate of postoperative pancreatic fistula, delayed gastric emptying, wound infection, shorter length of stay, and a higher R0 resection rate than robot-assisted pancreatoduodenectomy. In contrast, robot-assisted pancreatoduodenectomy was associated with a lower conversion rate and a higher number of retrieved lymph nodes as compared with laparoscopic pancreatoduodenectomy. |
| doi_str_mv | 10.1016/j.surg.2024.02.015 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3033011039</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0039606024000783</els_id><sourcerecordid>3033011039</sourcerecordid><originalsourceid>FETCH-LOGICAL-c351t-1329d16add26705c05dcdb3eec20dd2b4a5c8fb53acac1c9425b14662f7503013</originalsourceid><addsrcrecordid>eNp9kE1r3DAQhkVJabZp_0APxcde7I4ky7sbcgkhaQuBQknOQh7NJlpsy9FHYP99ZDbpMaeBmWdeZh7GvnFoOPDu576JOTw0AkTbgGiAqw9sxZUU9Vp2_IStAOS27qCDU_Y5xj0AbFu--cRO5UatQQi1YuM_3_tUmxhdTGSrZwoxx2owswk-op8dVrOZMJBJ3mZvaSJMfjycV2YZ1Nc5-JnMVI15SA5pShSqeelN0aVDPZqEjyU4pmwPX9jHnRkifX2tZ-z-5vru6nd9-_fXn6vL2xql4qnmUmwt74y1oluDQlAWbS-JUEDp9a1RuNn1Sho0yHHbCtXztuvEbq1AApdn7McxtxzylCkmPbqINAxmIp-jliALxouegoojiuXfGGin5-BGEw6ag140671eNOtFswahi-ay9P01P_cj2f8rb14LcHEEqHz57CjoiI4mJOtC8aetd-_lvwCgaZGx</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3033011039</pqid></control><display><type>article</type><title>Robot-assisted versus laparoscopic pancreatoduodenectomy: a pan-European multicenter propensity-matched study</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Emmen, Anouk M.L.H. ; Zwart, Maurice J.W. ; Khatkov, Igor E. ; Boggi, Ugo ; Groot Koerkamp, Bas ; Busch, Olivier R. ; Saint-Marc, Olivier ; Dokmak, Safi ; Molenaar, I. Quintus ; D’Hondt, Mathieu ; Ramera, Marco ; Keck, Tobias ; Ferrari, Giovanni ; Luyer, Misha D.P. ; Moraldi, Luca ; Ielpo, Benedetto ; Wittel, Uwe ; Souche, Francois-Regis ; Hackert, Thilo ; Lips, Daan ; Can, Mehmet Fatih ; Bosscha, Koop ; Fara, Regis ; Festen, Sebastiaan ; van Dieren, Susan ; Coratti, Andrea ; De Hingh, Ignace ; Mazzola, Michele ; Wellner, Ulrich ; De Meyere, Celine ; van Santvoort, Hjalmar C. ; Aussilhou, Béatrice ; Ibenkhayat, Abdallah ; de Wilde, Roeland F. ; Kauffmann, Emanuele F. ; Tyutyunnik, Pavel ; Besselink, Marc G. ; Abu Hilal, Mohammad ; Manzoni, Alberto ; Guerra, Martina ; Daams, Freek ; Kazemier, Geert ; Izrailov, Roman ; Efanov, Mikhail ; Napoli, Niccolò ; Ginesini, Michael ; Cappelle, Marie ; Haen, Roel ; Quetel, Romain ; Pucci, Marco ; Derksen, Wouter ; Hagendoorn, Jeroen ; Ftériche, Fadhel Samir ; Muzzolini, Milena ; Vansteenkiste, Franky ; Bolm, Louisa ; Winkel, Maike ten ; Giani, Alessandro ; Calcagno, Pietro</creator><creatorcontrib>Emmen, Anouk M.L.H. ; Zwart, Maurice J.W. ; Khatkov, Igor E. ; Boggi, Ugo ; Groot Koerkamp, Bas ; Busch, Olivier R. ; Saint-Marc, Olivier ; Dokmak, Safi ; Molenaar, I. Quintus ; D’Hondt, Mathieu ; Ramera, Marco ; Keck, Tobias ; Ferrari, Giovanni ; Luyer, Misha D.P. ; Moraldi, Luca ; Ielpo, Benedetto ; Wittel, Uwe ; Souche, Francois-Regis ; Hackert, Thilo ; Lips, Daan ; Can, Mehmet Fatih ; Bosscha, Koop ; Fara, Regis ; Festen, Sebastiaan ; van Dieren, Susan ; Coratti, Andrea ; De Hingh, Ignace ; Mazzola, Michele ; Wellner, Ulrich ; De Meyere, Celine ; van Santvoort, Hjalmar C. ; Aussilhou, Béatrice ; Ibenkhayat, Abdallah ; de Wilde, Roeland F. ; Kauffmann, Emanuele F. ; Tyutyunnik, Pavel ; Besselink, Marc G. ; Abu Hilal, Mohammad ; Manzoni, Alberto ; Guerra, Martina ; Daams, Freek ; Kazemier, Geert ; Izrailov, Roman ; Efanov, Mikhail ; Napoli, Niccolò ; Ginesini, Michael ; Cappelle, Marie ; Haen, Roel ; Quetel, Romain ; Pucci, Marco ; Derksen, Wouter ; Hagendoorn, Jeroen ; Ftériche, Fadhel Samir ; Muzzolini, Milena ; Vansteenkiste, Franky ; Bolm, Louisa ; Winkel, Maike ten ; Giani, Alessandro ; Calcagno, Pietro ; European consortium on Minimally Invasive Pancreatic Surgery (E-MIPS)</creatorcontrib><description>The use of robot-assisted and laparoscopic pancreatoduodenectomy is increasing, yet large adjusted analyses that can be generalized internationally are lacking. This study aimed to compare outcomes after robot-assisted pancreatoduodenectomy and laparoscopic pancreatoduodenectomy in a pan-European cohort.
An international multicenter retrospective study including patients after robot-assisted pancreatoduodenectomy and laparoscopic pancreatoduodenectomy from 50 centers in 12 European countries (2009–2020). Propensity score matching was performed in a 1:1 ratio. The primary outcome was major morbidity (Clavien–Dindo ≥III).
Among 2,082 patients undergoing minimally invasive pancreatoduodenectomy, 1,006 underwent robot-assisted pancreatoduodenectomy and 1,076 laparoscopic pancreatoduodenectomy. After matching 812 versus 812 patients, the rates of major morbidity (31.9% vs 29.6%; P = .347) and 30-day/in-hospital mortality (4.3% vs 4.6%; P = .904) did not differ significantly between robot-assisted pancreatoduodenectomy and laparoscopic pancreatoduodenectomy, respectively. Robot-assisted pancreatoduodenectomy was associated with a lower conversion rate (6.7% vs 18.0%; P < .001) and higher lymph node retrieval (16 vs 14; P = .003). Laparoscopic pancreatoduodenectomy was associated with shorter operation time (446 minutes versus 400 minutes; P < .001), and lower rates of postoperative pancreatic fistula grade B/C (19.0% vs 11.7%; P < .001), delayed gastric emptying grade B/C (21.4% vs 7.4%; P < .001), and a higher R0-resection rate (73.2% vs 84.4%; P < .001).
This European multicenter study found no differences in overall major morbidity and 30-day/in-hospital mortality after robot-assisted pancreatoduodenectomy compared with laparoscopic pancreatoduodenectomy. Further, laparoscopic pancreatoduodenectomy was associated with a lower rate of postoperative pancreatic fistula, delayed gastric emptying, wound infection, shorter length of stay, and a higher R0 resection rate than robot-assisted pancreatoduodenectomy. In contrast, robot-assisted pancreatoduodenectomy was associated with a lower conversion rate and a higher number of retrieved lymph nodes as compared with laparoscopic pancreatoduodenectomy.</description><identifier>ISSN: 0039-6060</identifier><identifier>ISSN: 1532-7361</identifier><identifier>EISSN: 1532-7361</identifier><identifier>DOI: 10.1016/j.surg.2024.02.015</identifier><identifier>PMID: 38570225</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Europe - epidemiology ; Female ; Hospital Mortality ; Humans ; Laparoscopy - adverse effects ; Laparoscopy - methods ; Male ; Middle Aged ; Pancreatic Neoplasms - mortality ; Pancreatic Neoplasms - surgery ; Pancreaticoduodenectomy - adverse effects ; Pancreaticoduodenectomy - methods ; Postoperative Complications - epidemiology ; Postoperative Complications - etiology ; Propensity Score ; Retrospective Studies ; Robotic Surgical Procedures - adverse effects ; Robotic Surgical Procedures - methods ; Treatment Outcome</subject><ispartof>Surgery, 2024-06, Vol.175 (6), p.1587-1594</ispartof><rights>2024 The Authors</rights><rights>Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c351t-1329d16add26705c05dcdb3eec20dd2b4a5c8fb53acac1c9425b14662f7503013</cites><orcidid>0000-0002-6481-4172 ; 0000-0001-7515-9276 ; 0000-0002-3084-0495 ; 0000-0002-7961-3314 ; 0000-0002-3546-197X ; 0000-0001-7634-4844 ; 0000-0001-9605-6831 ; 0000-0002-8442-5852 ; 0000-0001-7651-6183 ; 0000-0002-1961-5844</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0039606024000783$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38570225$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Emmen, Anouk M.L.H.</creatorcontrib><creatorcontrib>Zwart, Maurice J.W.</creatorcontrib><creatorcontrib>Khatkov, Igor E.</creatorcontrib><creatorcontrib>Boggi, Ugo</creatorcontrib><creatorcontrib>Groot Koerkamp, Bas</creatorcontrib><creatorcontrib>Busch, Olivier R.</creatorcontrib><creatorcontrib>Saint-Marc, Olivier</creatorcontrib><creatorcontrib>Dokmak, Safi</creatorcontrib><creatorcontrib>Molenaar, I. Quintus</creatorcontrib><creatorcontrib>D’Hondt, Mathieu</creatorcontrib><creatorcontrib>Ramera, Marco</creatorcontrib><creatorcontrib>Keck, Tobias</creatorcontrib><creatorcontrib>Ferrari, Giovanni</creatorcontrib><creatorcontrib>Luyer, Misha D.P.</creatorcontrib><creatorcontrib>Moraldi, Luca</creatorcontrib><creatorcontrib>Ielpo, Benedetto</creatorcontrib><creatorcontrib>Wittel, Uwe</creatorcontrib><creatorcontrib>Souche, Francois-Regis</creatorcontrib><creatorcontrib>Hackert, Thilo</creatorcontrib><creatorcontrib>Lips, Daan</creatorcontrib><creatorcontrib>Can, Mehmet Fatih</creatorcontrib><creatorcontrib>Bosscha, Koop</creatorcontrib><creatorcontrib>Fara, Regis</creatorcontrib><creatorcontrib>Festen, Sebastiaan</creatorcontrib><creatorcontrib>van Dieren, Susan</creatorcontrib><creatorcontrib>Coratti, Andrea</creatorcontrib><creatorcontrib>De Hingh, Ignace</creatorcontrib><creatorcontrib>Mazzola, Michele</creatorcontrib><creatorcontrib>Wellner, Ulrich</creatorcontrib><creatorcontrib>De Meyere, Celine</creatorcontrib><creatorcontrib>van Santvoort, Hjalmar C.</creatorcontrib><creatorcontrib>Aussilhou, Béatrice</creatorcontrib><creatorcontrib>Ibenkhayat, Abdallah</creatorcontrib><creatorcontrib>de Wilde, Roeland F.</creatorcontrib><creatorcontrib>Kauffmann, Emanuele F.</creatorcontrib><creatorcontrib>Tyutyunnik, Pavel</creatorcontrib><creatorcontrib>Besselink, Marc G.</creatorcontrib><creatorcontrib>Abu Hilal, Mohammad</creatorcontrib><creatorcontrib>Manzoni, Alberto</creatorcontrib><creatorcontrib>Guerra, Martina</creatorcontrib><creatorcontrib>Daams, Freek</creatorcontrib><creatorcontrib>Kazemier, Geert</creatorcontrib><creatorcontrib>Izrailov, Roman</creatorcontrib><creatorcontrib>Efanov, Mikhail</creatorcontrib><creatorcontrib>Napoli, Niccolò</creatorcontrib><creatorcontrib>Ginesini, Michael</creatorcontrib><creatorcontrib>Cappelle, Marie</creatorcontrib><creatorcontrib>Haen, Roel</creatorcontrib><creatorcontrib>Quetel, Romain</creatorcontrib><creatorcontrib>Pucci, Marco</creatorcontrib><creatorcontrib>Derksen, Wouter</creatorcontrib><creatorcontrib>Hagendoorn, Jeroen</creatorcontrib><creatorcontrib>Ftériche, Fadhel Samir</creatorcontrib><creatorcontrib>Muzzolini, Milena</creatorcontrib><creatorcontrib>Vansteenkiste, Franky</creatorcontrib><creatorcontrib>Bolm, Louisa</creatorcontrib><creatorcontrib>Winkel, Maike ten</creatorcontrib><creatorcontrib>Giani, Alessandro</creatorcontrib><creatorcontrib>Calcagno, Pietro</creatorcontrib><creatorcontrib>European consortium on Minimally Invasive Pancreatic Surgery (E-MIPS)</creatorcontrib><title>Robot-assisted versus laparoscopic pancreatoduodenectomy: a pan-European multicenter propensity-matched study</title><title>Surgery</title><addtitle>Surgery</addtitle><description>The use of robot-assisted and laparoscopic pancreatoduodenectomy is increasing, yet large adjusted analyses that can be generalized internationally are lacking. This study aimed to compare outcomes after robot-assisted pancreatoduodenectomy and laparoscopic pancreatoduodenectomy in a pan-European cohort.
An international multicenter retrospective study including patients after robot-assisted pancreatoduodenectomy and laparoscopic pancreatoduodenectomy from 50 centers in 12 European countries (2009–2020). Propensity score matching was performed in a 1:1 ratio. The primary outcome was major morbidity (Clavien–Dindo ≥III).
Among 2,082 patients undergoing minimally invasive pancreatoduodenectomy, 1,006 underwent robot-assisted pancreatoduodenectomy and 1,076 laparoscopic pancreatoduodenectomy. After matching 812 versus 812 patients, the rates of major morbidity (31.9% vs 29.6%; P = .347) and 30-day/in-hospital mortality (4.3% vs 4.6%; P = .904) did not differ significantly between robot-assisted pancreatoduodenectomy and laparoscopic pancreatoduodenectomy, respectively. Robot-assisted pancreatoduodenectomy was associated with a lower conversion rate (6.7% vs 18.0%; P < .001) and higher lymph node retrieval (16 vs 14; P = .003). Laparoscopic pancreatoduodenectomy was associated with shorter operation time (446 minutes versus 400 minutes; P < .001), and lower rates of postoperative pancreatic fistula grade B/C (19.0% vs 11.7%; P < .001), delayed gastric emptying grade B/C (21.4% vs 7.4%; P < .001), and a higher R0-resection rate (73.2% vs 84.4%; P < .001).
This European multicenter study found no differences in overall major morbidity and 30-day/in-hospital mortality after robot-assisted pancreatoduodenectomy compared with laparoscopic pancreatoduodenectomy. Further, laparoscopic pancreatoduodenectomy was associated with a lower rate of postoperative pancreatic fistula, delayed gastric emptying, wound infection, shorter length of stay, and a higher R0 resection rate than robot-assisted pancreatoduodenectomy. In contrast, robot-assisted pancreatoduodenectomy was associated with a lower conversion rate and a higher number of retrieved lymph nodes as compared with laparoscopic pancreatoduodenectomy.</description><subject>Aged</subject><subject>Europe - epidemiology</subject><subject>Female</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Laparoscopy - adverse effects</subject><subject>Laparoscopy - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pancreatic Neoplasms - mortality</subject><subject>Pancreatic Neoplasms - surgery</subject><subject>Pancreaticoduodenectomy - adverse effects</subject><subject>Pancreaticoduodenectomy - methods</subject><subject>Postoperative Complications - epidemiology</subject><subject>Postoperative Complications - etiology</subject><subject>Propensity Score</subject><subject>Retrospective Studies</subject><subject>Robotic Surgical Procedures - adverse effects</subject><subject>Robotic Surgical Procedures - methods</subject><subject>Treatment Outcome</subject><issn>0039-6060</issn><issn>1532-7361</issn><issn>1532-7361</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVJabZp_0APxcde7I4ky7sbcgkhaQuBQknOQh7NJlpsy9FHYP99ZDbpMaeBmWdeZh7GvnFoOPDu576JOTw0AkTbgGiAqw9sxZUU9Vp2_IStAOS27qCDU_Y5xj0AbFu--cRO5UatQQi1YuM_3_tUmxhdTGSrZwoxx2owswk-op8dVrOZMJBJ3mZvaSJMfjycV2YZ1Nc5-JnMVI15SA5pShSqeelN0aVDPZqEjyU4pmwPX9jHnRkifX2tZ-z-5vru6nd9-_fXn6vL2xql4qnmUmwt74y1oluDQlAWbS-JUEDp9a1RuNn1Sho0yHHbCtXztuvEbq1AApdn7McxtxzylCkmPbqINAxmIp-jliALxouegoojiuXfGGin5-BGEw6ag140671eNOtFswahi-ay9P01P_cj2f8rb14LcHEEqHz57CjoiI4mJOtC8aetd-_lvwCgaZGx</recordid><startdate>202406</startdate><enddate>202406</enddate><creator>Emmen, Anouk M.L.H.</creator><creator>Zwart, Maurice J.W.</creator><creator>Khatkov, Igor E.</creator><creator>Boggi, Ugo</creator><creator>Groot Koerkamp, Bas</creator><creator>Busch, Olivier R.</creator><creator>Saint-Marc, Olivier</creator><creator>Dokmak, Safi</creator><creator>Molenaar, I. Quintus</creator><creator>D’Hondt, Mathieu</creator><creator>Ramera, Marco</creator><creator>Keck, Tobias</creator><creator>Ferrari, Giovanni</creator><creator>Luyer, Misha D.P.</creator><creator>Moraldi, Luca</creator><creator>Ielpo, Benedetto</creator><creator>Wittel, Uwe</creator><creator>Souche, Francois-Regis</creator><creator>Hackert, Thilo</creator><creator>Lips, Daan</creator><creator>Can, Mehmet Fatih</creator><creator>Bosscha, Koop</creator><creator>Fara, Regis</creator><creator>Festen, Sebastiaan</creator><creator>van Dieren, Susan</creator><creator>Coratti, Andrea</creator><creator>De Hingh, Ignace</creator><creator>Mazzola, Michele</creator><creator>Wellner, Ulrich</creator><creator>De Meyere, Celine</creator><creator>van Santvoort, Hjalmar C.</creator><creator>Aussilhou, Béatrice</creator><creator>Ibenkhayat, Abdallah</creator><creator>de Wilde, Roeland F.</creator><creator>Kauffmann, Emanuele F.</creator><creator>Tyutyunnik, Pavel</creator><creator>Besselink, Marc G.</creator><creator>Abu Hilal, Mohammad</creator><creator>Manzoni, Alberto</creator><creator>Guerra, Martina</creator><creator>Daams, Freek</creator><creator>Kazemier, Geert</creator><creator>Izrailov, Roman</creator><creator>Efanov, Mikhail</creator><creator>Napoli, Niccolò</creator><creator>Ginesini, Michael</creator><creator>Cappelle, Marie</creator><creator>Haen, Roel</creator><creator>Quetel, Romain</creator><creator>Pucci, Marco</creator><creator>Derksen, Wouter</creator><creator>Hagendoorn, Jeroen</creator><creator>Ftériche, Fadhel Samir</creator><creator>Muzzolini, Milena</creator><creator>Vansteenkiste, Franky</creator><creator>Bolm, Louisa</creator><creator>Winkel, Maike ten</creator><creator>Giani, Alessandro</creator><creator>Calcagno, Pietro</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6481-4172</orcidid><orcidid>https://orcid.org/0000-0001-7515-9276</orcidid><orcidid>https://orcid.org/0000-0002-3084-0495</orcidid><orcidid>https://orcid.org/0000-0002-7961-3314</orcidid><orcidid>https://orcid.org/0000-0002-3546-197X</orcidid><orcidid>https://orcid.org/0000-0001-7634-4844</orcidid><orcidid>https://orcid.org/0000-0001-9605-6831</orcidid><orcidid>https://orcid.org/0000-0002-8442-5852</orcidid><orcidid>https://orcid.org/0000-0001-7651-6183</orcidid><orcidid>https://orcid.org/0000-0002-1961-5844</orcidid></search><sort><creationdate>202406</creationdate><title>Robot-assisted versus laparoscopic pancreatoduodenectomy: a pan-European multicenter propensity-matched study</title><author>Emmen, Anouk M.L.H. ; Zwart, Maurice J.W. ; Khatkov, Igor E. ; Boggi, Ugo ; Groot Koerkamp, Bas ; Busch, Olivier R. ; Saint-Marc, Olivier ; Dokmak, Safi ; Molenaar, I. Quintus ; D’Hondt, Mathieu ; Ramera, Marco ; Keck, Tobias ; Ferrari, Giovanni ; Luyer, Misha D.P. ; Moraldi, Luca ; Ielpo, Benedetto ; Wittel, Uwe ; Souche, Francois-Regis ; Hackert, Thilo ; Lips, Daan ; Can, Mehmet Fatih ; Bosscha, Koop ; Fara, Regis ; Festen, Sebastiaan ; van Dieren, Susan ; Coratti, Andrea ; De Hingh, Ignace ; Mazzola, Michele ; Wellner, Ulrich ; De Meyere, Celine ; van Santvoort, Hjalmar C. ; Aussilhou, Béatrice ; Ibenkhayat, Abdallah ; de Wilde, Roeland F. ; Kauffmann, Emanuele F. ; Tyutyunnik, Pavel ; Besselink, Marc G. ; Abu Hilal, Mohammad ; Manzoni, Alberto ; Guerra, Martina ; Daams, Freek ; Kazemier, Geert ; Izrailov, Roman ; Efanov, Mikhail ; Napoli, Niccolò ; Ginesini, Michael ; Cappelle, Marie ; Haen, Roel ; Quetel, Romain ; Pucci, Marco ; Derksen, Wouter ; Hagendoorn, Jeroen ; Ftériche, Fadhel Samir ; Muzzolini, Milena ; Vansteenkiste, Franky ; Bolm, Louisa ; Winkel, Maike ten ; Giani, Alessandro ; Calcagno, Pietro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-1329d16add26705c05dcdb3eec20dd2b4a5c8fb53acac1c9425b14662f7503013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Europe - epidemiology</topic><topic>Female</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Laparoscopy - adverse effects</topic><topic>Laparoscopy - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pancreatic Neoplasms - mortality</topic><topic>Pancreatic Neoplasms - surgery</topic><topic>Pancreaticoduodenectomy - adverse effects</topic><topic>Pancreaticoduodenectomy - methods</topic><topic>Postoperative Complications - epidemiology</topic><topic>Postoperative Complications - etiology</topic><topic>Propensity Score</topic><topic>Retrospective Studies</topic><topic>Robotic Surgical Procedures - adverse effects</topic><topic>Robotic Surgical Procedures - methods</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Emmen, Anouk M.L.H.</creatorcontrib><creatorcontrib>Zwart, Maurice J.W.</creatorcontrib><creatorcontrib>Khatkov, Igor E.</creatorcontrib><creatorcontrib>Boggi, Ugo</creatorcontrib><creatorcontrib>Groot Koerkamp, Bas</creatorcontrib><creatorcontrib>Busch, Olivier R.</creatorcontrib><creatorcontrib>Saint-Marc, Olivier</creatorcontrib><creatorcontrib>Dokmak, Safi</creatorcontrib><creatorcontrib>Molenaar, I. Quintus</creatorcontrib><creatorcontrib>D’Hondt, Mathieu</creatorcontrib><creatorcontrib>Ramera, Marco</creatorcontrib><creatorcontrib>Keck, Tobias</creatorcontrib><creatorcontrib>Ferrari, Giovanni</creatorcontrib><creatorcontrib>Luyer, Misha D.P.</creatorcontrib><creatorcontrib>Moraldi, Luca</creatorcontrib><creatorcontrib>Ielpo, Benedetto</creatorcontrib><creatorcontrib>Wittel, Uwe</creatorcontrib><creatorcontrib>Souche, Francois-Regis</creatorcontrib><creatorcontrib>Hackert, Thilo</creatorcontrib><creatorcontrib>Lips, Daan</creatorcontrib><creatorcontrib>Can, Mehmet Fatih</creatorcontrib><creatorcontrib>Bosscha, Koop</creatorcontrib><creatorcontrib>Fara, Regis</creatorcontrib><creatorcontrib>Festen, Sebastiaan</creatorcontrib><creatorcontrib>van Dieren, Susan</creatorcontrib><creatorcontrib>Coratti, Andrea</creatorcontrib><creatorcontrib>De Hingh, Ignace</creatorcontrib><creatorcontrib>Mazzola, Michele</creatorcontrib><creatorcontrib>Wellner, Ulrich</creatorcontrib><creatorcontrib>De Meyere, Celine</creatorcontrib><creatorcontrib>van Santvoort, Hjalmar C.</creatorcontrib><creatorcontrib>Aussilhou, Béatrice</creatorcontrib><creatorcontrib>Ibenkhayat, Abdallah</creatorcontrib><creatorcontrib>de Wilde, Roeland F.</creatorcontrib><creatorcontrib>Kauffmann, Emanuele F.</creatorcontrib><creatorcontrib>Tyutyunnik, Pavel</creatorcontrib><creatorcontrib>Besselink, Marc G.</creatorcontrib><creatorcontrib>Abu Hilal, Mohammad</creatorcontrib><creatorcontrib>Manzoni, Alberto</creatorcontrib><creatorcontrib>Guerra, Martina</creatorcontrib><creatorcontrib>Daams, Freek</creatorcontrib><creatorcontrib>Kazemier, Geert</creatorcontrib><creatorcontrib>Izrailov, Roman</creatorcontrib><creatorcontrib>Efanov, Mikhail</creatorcontrib><creatorcontrib>Napoli, Niccolò</creatorcontrib><creatorcontrib>Ginesini, Michael</creatorcontrib><creatorcontrib>Cappelle, Marie</creatorcontrib><creatorcontrib>Haen, Roel</creatorcontrib><creatorcontrib>Quetel, Romain</creatorcontrib><creatorcontrib>Pucci, Marco</creatorcontrib><creatorcontrib>Derksen, Wouter</creatorcontrib><creatorcontrib>Hagendoorn, Jeroen</creatorcontrib><creatorcontrib>Ftériche, Fadhel Samir</creatorcontrib><creatorcontrib>Muzzolini, Milena</creatorcontrib><creatorcontrib>Vansteenkiste, Franky</creatorcontrib><creatorcontrib>Bolm, Louisa</creatorcontrib><creatorcontrib>Winkel, Maike ten</creatorcontrib><creatorcontrib>Giani, Alessandro</creatorcontrib><creatorcontrib>Calcagno, Pietro</creatorcontrib><creatorcontrib>European consortium on Minimally Invasive Pancreatic Surgery (E-MIPS)</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Emmen, Anouk M.L.H.</au><au>Zwart, Maurice J.W.</au><au>Khatkov, Igor E.</au><au>Boggi, Ugo</au><au>Groot Koerkamp, Bas</au><au>Busch, Olivier R.</au><au>Saint-Marc, Olivier</au><au>Dokmak, Safi</au><au>Molenaar, I. Quintus</au><au>D’Hondt, Mathieu</au><au>Ramera, Marco</au><au>Keck, Tobias</au><au>Ferrari, Giovanni</au><au>Luyer, Misha D.P.</au><au>Moraldi, Luca</au><au>Ielpo, Benedetto</au><au>Wittel, Uwe</au><au>Souche, Francois-Regis</au><au>Hackert, Thilo</au><au>Lips, Daan</au><au>Can, Mehmet Fatih</au><au>Bosscha, Koop</au><au>Fara, Regis</au><au>Festen, Sebastiaan</au><au>van Dieren, Susan</au><au>Coratti, Andrea</au><au>De Hingh, Ignace</au><au>Mazzola, Michele</au><au>Wellner, Ulrich</au><au>De Meyere, Celine</au><au>van Santvoort, Hjalmar C.</au><au>Aussilhou, Béatrice</au><au>Ibenkhayat, Abdallah</au><au>de Wilde, Roeland F.</au><au>Kauffmann, Emanuele F.</au><au>Tyutyunnik, Pavel</au><au>Besselink, Marc G.</au><au>Abu Hilal, Mohammad</au><au>Manzoni, Alberto</au><au>Guerra, Martina</au><au>Daams, Freek</au><au>Kazemier, Geert</au><au>Izrailov, Roman</au><au>Efanov, Mikhail</au><au>Napoli, Niccolò</au><au>Ginesini, Michael</au><au>Cappelle, Marie</au><au>Haen, Roel</au><au>Quetel, Romain</au><au>Pucci, Marco</au><au>Derksen, Wouter</au><au>Hagendoorn, Jeroen</au><au>Ftériche, Fadhel Samir</au><au>Muzzolini, Milena</au><au>Vansteenkiste, Franky</au><au>Bolm, Louisa</au><au>Winkel, Maike ten</au><au>Giani, Alessandro</au><au>Calcagno, Pietro</au><aucorp>European consortium on Minimally Invasive Pancreatic Surgery (E-MIPS)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Robot-assisted versus laparoscopic pancreatoduodenectomy: a pan-European multicenter propensity-matched study</atitle><jtitle>Surgery</jtitle><addtitle>Surgery</addtitle><date>2024-06</date><risdate>2024</risdate><volume>175</volume><issue>6</issue><spage>1587</spage><epage>1594</epage><pages>1587-1594</pages><issn>0039-6060</issn><issn>1532-7361</issn><eissn>1532-7361</eissn><abstract>The use of robot-assisted and laparoscopic pancreatoduodenectomy is increasing, yet large adjusted analyses that can be generalized internationally are lacking. This study aimed to compare outcomes after robot-assisted pancreatoduodenectomy and laparoscopic pancreatoduodenectomy in a pan-European cohort.
An international multicenter retrospective study including patients after robot-assisted pancreatoduodenectomy and laparoscopic pancreatoduodenectomy from 50 centers in 12 European countries (2009–2020). Propensity score matching was performed in a 1:1 ratio. The primary outcome was major morbidity (Clavien–Dindo ≥III).
Among 2,082 patients undergoing minimally invasive pancreatoduodenectomy, 1,006 underwent robot-assisted pancreatoduodenectomy and 1,076 laparoscopic pancreatoduodenectomy. After matching 812 versus 812 patients, the rates of major morbidity (31.9% vs 29.6%; P = .347) and 30-day/in-hospital mortality (4.3% vs 4.6%; P = .904) did not differ significantly between robot-assisted pancreatoduodenectomy and laparoscopic pancreatoduodenectomy, respectively. Robot-assisted pancreatoduodenectomy was associated with a lower conversion rate (6.7% vs 18.0%; P < .001) and higher lymph node retrieval (16 vs 14; P = .003). Laparoscopic pancreatoduodenectomy was associated with shorter operation time (446 minutes versus 400 minutes; P < .001), and lower rates of postoperative pancreatic fistula grade B/C (19.0% vs 11.7%; P < .001), delayed gastric emptying grade B/C (21.4% vs 7.4%; P < .001), and a higher R0-resection rate (73.2% vs 84.4%; P < .001).
This European multicenter study found no differences in overall major morbidity and 30-day/in-hospital mortality after robot-assisted pancreatoduodenectomy compared with laparoscopic pancreatoduodenectomy. Further, laparoscopic pancreatoduodenectomy was associated with a lower rate of postoperative pancreatic fistula, delayed gastric emptying, wound infection, shorter length of stay, and a higher R0 resection rate than robot-assisted pancreatoduodenectomy. In contrast, robot-assisted pancreatoduodenectomy was associated with a lower conversion rate and a higher number of retrieved lymph nodes as compared with laparoscopic pancreatoduodenectomy.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>38570225</pmid><doi>10.1016/j.surg.2024.02.015</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6481-4172</orcidid><orcidid>https://orcid.org/0000-0001-7515-9276</orcidid><orcidid>https://orcid.org/0000-0002-3084-0495</orcidid><orcidid>https://orcid.org/0000-0002-7961-3314</orcidid><orcidid>https://orcid.org/0000-0002-3546-197X</orcidid><orcidid>https://orcid.org/0000-0001-7634-4844</orcidid><orcidid>https://orcid.org/0000-0001-9605-6831</orcidid><orcidid>https://orcid.org/0000-0002-8442-5852</orcidid><orcidid>https://orcid.org/0000-0001-7651-6183</orcidid><orcidid>https://orcid.org/0000-0002-1961-5844</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0039-6060 |
| ispartof | Surgery, 2024-06, Vol.175 (6), p.1587-1594 |
| issn | 0039-6060 1532-7361 1532-7361 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3033011039 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Europe - epidemiology Female Hospital Mortality Humans Laparoscopy - adverse effects Laparoscopy - methods Male Middle Aged Pancreatic Neoplasms - mortality Pancreatic Neoplasms - surgery Pancreaticoduodenectomy - adverse effects Pancreaticoduodenectomy - methods Postoperative Complications - epidemiology Postoperative Complications - etiology Propensity Score Retrospective Studies Robotic Surgical Procedures - adverse effects Robotic Surgical Procedures - methods Treatment Outcome |
| title | Robot-assisted versus laparoscopic pancreatoduodenectomy: a pan-European multicenter propensity-matched study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T05%3A17%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Robot-assisted%20versus%20laparoscopic%20pancreatoduodenectomy:%20a%20pan-European%20multicenter%20propensity-matched%20study&rft.jtitle=Surgery&rft.au=Emmen,%20Anouk%20M.L.H.&rft.aucorp=European%20consortium%20on%20Minimally%20Invasive%20Pancreatic%20Surgery%20(E-MIPS)&rft.date=2024-06&rft.volume=175&rft.issue=6&rft.spage=1587&rft.epage=1594&rft.pages=1587-1594&rft.issn=0039-6060&rft.eissn=1532-7361&rft_id=info:doi/10.1016/j.surg.2024.02.015&rft_dat=%3Cproquest_cross%3E3033011039%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3033011039&rft_id=info:pmid/38570225&rft_els_id=S0039606024000783&rfr_iscdi=true |